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mtdha metadherin a [ Danio rerio (zebrafish) ]

Gene ID: 368910, updated on 4-Jan-2025

Summary

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Official Symbol
mtdhaprovided by ZNC
Official Full Name
metadherin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030616-615
See related
Ensembl:ENSDARG00000014159 AllianceGenome:ZFIN:ZDB-GENE-030616-615
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
lyric; lyricl; wu:fc33g06; si:zc215i13.6
Summary
Predicted to act upstream of or within negative regulation of apoptotic process; positive regulation of angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane and nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See mtdha in Genome Data Viewer
Location:
chromosome: 19
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (32895379..32914231, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (33308259..33327180, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30 Neighboring gene lysosomal protein transmembrane 4 beta Neighboring gene ribonucleotide reductase M2 b Neighboring gene antizyme inhibitor 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
  2. Positive correlation between gene coexpression and positional clustering in the zebrafish genome. Ng YK, et al. BMC Genomics, 2009 Jan 22. PMID 19159490, Free PMC Article
  3. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
metadherin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007135.2 → NP_001007136.2  metadherin a

    See identical proteins and their annotated locations for NP_001007136.2

    Status: PROVISIONAL

    Source sequence(s)
    BC068430
    UniProtKB/TrEMBL
    Q6NUU0
    Related
    ENSDARP00000147602.1, ENSDART00000186115.1
    Conserved Domains (1) summary
    pfam15686
    Location:5 → 445
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    32895379..32914231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159603.4 → XP_005159660.1  metadherin a isoform X2

    UniProtKB/TrEMBL
    A0A8M2B6D6, A8DZ70, E7EZ81
    Related
    ENSDARP00000111658.2, ENSDART00000124246.4
    Conserved Domains (1) summary
    pfam15686
    Location:5 → 446
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  2. XM_005159604.4 → XP_005159661.1  metadherin a isoform X3

    UniProtKB/TrEMBL
    A0A2R8QJH1, A0A8M2B6A1
    Conserved Domains (1) summary
    pfam15686
    Location:5 → 446
    LYRIC; Lysine-rich CEACAM1 co-isolated protein family

  3. XM_017352195.3 → XP_017207684.1  metadherin a isoform X1

    UniProtKB/TrEMBL
    A0A8M6YWB0

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395056.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    32029..50877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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