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Ehbp1 Eps15 homology domain containing protein-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36912, updated on 4-Jan-2025

Summary

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Official Symbol
Ehbp1provided by FlyBase
Official Full Name
Eps15 homology domain containing protein-binding protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0034180
Locus tag
Dmel_CG15609
See related
AllianceGenome:FB:FBgn0034180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2R11; CG15609; dEHBP-1; dEHBP1; Dmel\CG15609; ehbp1; EHBP1
Summary
Involved in several processes, including positive regulation of Notch signaling pathway; secretion by cell; and sensory organ precursor cell division. Located in cell cortex and plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to several human genes including EHBP1 (EH domain binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ehbp1 in Genome Data Viewer
Location:
53E4-53E4; 2-81 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17007674..17015894, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12895179..12903399, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene Nuclear inhibitor of Protein phosphatase 1 Neighboring gene uncharacterized protein Neighboring gene Poly(A) binding protein interacting protein 1 Neighboring gene Death-associated APAF1-related killer Neighboring gene antisense RNA:CR44390

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Constriction imposed by basement membrane regulates developmental cell migration. Molina López E, et al. PLoS Biol, 2023 Jun. PMID 37379333, Free PMC Article
  2. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. Giagtzoglou N, et al. J Cell Sci, 2013 Aug 15. PMID 23788431, Free PMC Article
  3. Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. Ulvila J, et al. J Leukoc Biol, 2011 May. PMID 21208897
  4. Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis. Isabella AJ, et al. Dev Cell, 2016 Jul 11. PMID 27404358, Free PMC Article
  5. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in basement membrane constituent secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basolateral protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ precursor cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Eps15 homology domain containing protein-binding protein 1
Names
CG15609-PB
CG15609-PF
CG15609-PG
CG15609-PI
Ehbp1-PB
Ehbp1-PF
Ehbp1-PG
Ehbp1-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17007674..17015894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144211.2 → NP_001137683.2  Eps15 homology domain containing protein-binding protein 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137683.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZI1, Q8MR93
    Conserved Domains (3) summary
    cd00014
    Location:460 → 562
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:835 → 975
    DUF3585; Protein of unknown function (DUF3585)

  2. NM_206144.2 → NP_995866.1  Eps15 homology domain containing protein-binding protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995866.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZL2, Q8MR93
    Conserved Domains (3) summary
    cd00014
    Location:460 → 562
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:828 → 968
    DUF3585; Protein of unknown function (DUF3585)

  3. NM_137335.4 → NP_611179.3  Eps15 homology domain containing protein-binding protein 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611179.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAN2, Q8MR93
    Conserved Domains (3) summary
    cd00014
    Location:438 → 540
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:806 → 946
    DUF3585; Protein of unknown function (DUF3585)

  4. NM_206143.3 → NP_995865.2  Eps15 homology domain containing protein-binding protein 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995865.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4UZL3, Q8MR93
    Conserved Domains (3) summary
    cd00014
    Location:460 → 562
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam10358
    Location:12 → 165
    NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
    pfam12130
    Location:1027 → 1122
    DUF3585; Protein of unknown function (DUF3585)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAN2 A1ZAN2
A4UZL2 A4UZL2
A4UZL3 A4UZL3
B7YZI1 B7YZI1
Q8MR93 Q8MR93

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