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CG8950 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36921, updated on 4-Jan-2025

Summary

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Official Symbol
CG8950provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034186
Locus tag
Dmel_CG8950
See related
AllianceGenome:FB:FBgn0034186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8950
Summary
Predicted to be involved in transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIC complex. Is expressed in organism. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG8950 in Genome Data Viewer
Location:
53F3-53F4; 2-81 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17059331..17062634, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12946836..12950139, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fat-spondin Neighboring gene teflon Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan CD box 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels. Chen HL, et al. G3 (Bethesda), 2020 Apr 9. PMID 32054635, Free PMC Article
  2. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Gilchrist DA, et al. Cell, 2010 Nov 12. PMID 21074046, Free PMC Article
  3. Analysis of insect nuclear small heat shock proteins and interacting proteins. Moutaoufik MT, et al. Cell Stress Chaperones, 2021 Jan. PMID 32888179, Free PMC Article
  4. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Somma MP, et al. PLoS Genet, 2008 Jul 18. PMID 18797514, Free PMC Article
  5. Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. Izutsu M, et al. PLoS One, 2012. PMID 22432011, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8950-PA
CG8950-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17059331..17062634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259455.2 → NP_001246384.1  uncharacterized protein Dmel_CG8950, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVW5
    Conserved Domains (4) summary
    COG0457
    Location:219 → 497
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:402 → 430
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:795 → 864
    TPR_12; Tetratricopeptide repeat
    pfam14559
    Location:448 → 510
    TPR_19; Tetratricopeptide repeat

  2. NM_137340.3 → NP_611184.1  uncharacterized protein Dmel_CG8950, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611184.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JVW5
    Related
    FBpp0086164
    Conserved Domains (4) summary
    COG0457
    Location:219 → 497
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:402 → 430
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:795 → 864
    TPR_12; Tetratricopeptide repeat
    pfam14559
    Location:448 → 510
    TPR_19; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JVW5 Q7JVW5

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