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Mov10 Mov10 RISC complex RNA helicase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36922, updated on 9-Dec-2024

Summary

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Official Symbol
Mov10provided by FlyBase
Official Full Name
Mov10 RISC complex RNA helicaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034187
Locus tag
Dmel_CG6967
See related
AllianceGenome:FB:FBgn0034187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6967; CT21565; Dmel\CG6967; dMOV10
Summary
Enables RISC complex binding activity and sequence-specific mRNA binding activity. Involved in positive regulation of miRNA-mediated gene silencing. Located in cytosol. Is expressed in germline cell; gonad; organism; and primordial germ cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mov10 in Genome Data Viewer
Location:
53F4-53F4; 2-81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17062775..17066546)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12950280..12954051)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene fat-spondin Neighboring gene teflon Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan CD box 17 Neighboring gene Sphingosine-1-phosphate lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels. Chen HL, et al. G3 (Bethesda), 2020 Apr 9. PMID 32054635, Free PMC Article
  2. Drosophila MOV10 regulates the termination of midgut regeneration. Takemura M, et al. Genetics, 2021 May 17. PMID 33693718, Free PMC Article
  3. Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2'3'-cGAMP Responses. Hédelin L, et al. Mol Biol Evol, 2024 Mar 1. PMID 38377349, Free PMC Article
  4. Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes. Yurkevych IS, et al. Biogerontology, 2020 Oct. PMID 32468146
  5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila MOV10 regulates the termination of midgut regeneration.
    Title: Drosophila MOV10 regulates the termination of midgut regeneration.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-3' RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5'-3' RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RISC complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of miRNA-mediated gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mov10 RISC complex RNA helicase
Names
CG6967-PC
CG6967-PD
Mov10-PC
Mov10-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17062775..17066546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166214.3 → NP_725650.3  Mov10 RISC complex RNA helicase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725650.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAP7, Q8MRI1, Q9V7X9
    Conserved Domains (3) summary
    pfam13086
    Location:251 → 456
    AAA_11; AAA domain
    pfam13245
    Location:256 → 323
    AAA_19; Part of AAA domain
    cl22977
    Location:464 → 665
    UvrD_C_2; UvrD-like helicase C-terminal domain

  2. NM_137341.3 → NP_611185.3  Mov10 RISC complex RNA helicase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611185.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAP7, Q8MRI1, Q9V7X9
    Conserved Domains (3) summary
    pfam13086
    Location:251 → 456
    AAA_11; AAA domain
    pfam13245
    Location:256 → 323
    AAA_19; Part of AAA domain
    cl22977
    Location:464 → 665
    UvrD_C_2; UvrD-like helicase C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAP7 A1ZAP7
Q8MRI1 Q8MRI1

Gene LinkOut

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