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CG46491 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36929, updated on 9-Dec-2024

Summary

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Official Symbol
CG46491provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0287631
Locus tag
Dmel_CG46491
See related
AllianceGenome:FB:FBgn0287631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15612; CG15613; CG30456; Dmel\CG46491
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis. Is expressed in leg and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG46491 in Genome Data Viewer
Location:
53F8-53F9; 2-81 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17100241..17107542)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12987746..12995047)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase S1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Amylase proximal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Ma Z, et al. Genetics, 2012 Apr. PMID 22234859, Free PMC Article
  2. Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. Noyes A, et al. G3 (Bethesda), 2011 Nov. PMID 22384357, Free PMC Article
  3. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
  4. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
  5. Systematic analysis of RhoGEF/GAP localizations uncovers regulators of mechanosensing and junction formation during epithelial cell division. di Pietro F, et al. Curr Biol, 2023 Mar 13. PMID 36917931, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG46491-PB
CG46491-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17100241..17107542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137344.4 → NP_611188.3  uncharacterized protein Dmel_CG46491, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611188.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAQ3, Q960B3
    Conserved Domains (1) summary
    pfam00621
    Location:326 → 470
    RhoGEF; RhoGEF domain

  2. NM_001274112.1 → NP_001261041.1  uncharacterized protein Dmel_CG46491, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261041.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEX9, Q960B3
    Conserved Domains (1) summary
    pfam00621
    Location:236 → 380
    RhoGEF; RhoGEF domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEX9 A0A0B4KEX9

Gene LinkOut

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