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veil veil [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36968, updated on 9-Dec-2024

Summary

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Official Symbol
veilprovided by FlyBase
Official Full Name
veilprovided by FlyBase
Primary source
FLYBASE:FBgn0034225
Locus tag
Dmel_CG4827
See related
AllianceGenome:FB:FBgn0034225
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4827; Dmel\CG4827; NT5E-1; NT5E1
Summary
Enables 5'-nucleotidase activity. Predicted to be involved in AMP catabolic process. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; anlage in statu nascendi; dorsal ectoderm; dorsal ectoderm anlage; and hindgut anlage. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See veil in Genome Data Viewer
Location:
54B16-54B17; 2-82 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17478158..17482118)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13365663..13369623)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene quaking related 54B Neighboring gene insensible Neighboring gene uncharacterized protein Neighboring gene Ecto-5'-nucleotidase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of ecto-5'-nucleotidases and apyrases in Drosophila melanogaster. Fenckova M, et al. Insect Biochem Mol Biol, 2011 Dec. PMID 21996016
  2. Delineating Purinergic Signaling in Drosophila. Volonté C, et al. Int J Mol Sci, 2022 Dec 2. PMID 36499534, Free PMC Article
  3. Epithelial cells release adenosine to promote local TNF production in response to polarity disruption. Poernbacher I, et al. Nat Commun, 2018 Nov 7. PMID 30405122, Free PMC Article
  4. A new genetic locus controlling growth and proliferation in Drosophila melanogaster. Raisin S, et al. Genetics, 2003 Jul. PMID 12871911, Free PMC Article
  5. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Xu C, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31852821, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
veil
Names
5' nucleotidase precursor
5'-nucleotidase-precursor
CG4827-PA
CG4827-PB
veil-PA
veil-PB
NP_001286533.1
NP_611217.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17478158..17482118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299604.1 → NP_001286533.1  veil, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286533.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0L5
    Conserved Domains (3) summary
    COG0737
    Location:14 → 556
    UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
    cd07409
    Location:37 → 330
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:358 → 528
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain

  2. NM_137373.3 → NP_611217.1  veil, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611217.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0L5
    Related
    FBpp0086082
    Conserved Domains (3) summary
    COG0737
    Location:14 → 556
    UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
    cd07409
    Location:37 → 330
    MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
    pfam02872
    Location:358 → 528
    5_nucleotid_C; 5'-nucleotidase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0L5 Q7K0L5

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