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RhoGAP54D Rho GTPase activating protein at 54D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36996, updated on 9-Dec-2024

Summary

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Official Symbol
RhoGAP54Dprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 54Dprovided by FlyBase
Primary source
FLYBASE:FBgn0034249
Locus tag
Dmel_CG6477
See related
AllianceGenome:FB:FBgn0034249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6477; Dmel\CG6477
Summary
Predicted to enable GTPase activator activity. Involved in imaginal disc-derived leg morphogenesis. Predicted to be active in cytoplasm. Is expressed in leg. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See RhoGAP54D in Genome Data Viewer
Location:
54C11-54C12; 2-83 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17586425..17590884, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13473930..13478389, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45274 Neighboring gene antisense RNA:CR45275 Neighboring gene uncharacterized protein Neighboring gene icln Neighboring gene uncharacterized protein Neighboring gene SMAD specific E3 ubiquitin protein ligase Neighboring gene NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
  2. Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway. Billuart P, et al. Cell, 2001 Oct 19. PMID 11672527
  3. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis. Greenberg L, et al. Mech Dev, 2011 Jan-Feb. PMID 20851182, Free PMC Article
  4. The nonspecific lethal complex is a transcriptional regulator in Drosophila. Raja SJ, et al. Mol Cell, 2010 Jun 25. PMID 20620954
  5. Sin3a acts through a multi-gene module to regulate invasion in Drosophila and human tumors. Das TK, et al. Oncogene, 2013 Jun 27. PMID 22890320, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein at 54D
Names
CG6477-PA
CG6477-PC
RhoGAP54D-PA
RhoGAP54D-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17586425..17590884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137392.3 → NP_611236.2  Rho GTPase activating protein at 54D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611236.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAW3, Q058T7
    Related
    FBpp0086058
    Conserved Domains (1) summary
    cl02570
    Location:107 → 313
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  2. NM_001274131.2 → NP_001261060.1  Rho GTPase activating protein at 54D, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAW3, Q058T7
    Conserved Domains (1) summary
    cl02570
    Location:107 → 313
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAW3 A1ZAW3
Q8IGY7 Q8IGY7

Gene LinkOut

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