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Hyccin hyccin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37019, updated on 9-Dec-2024

Summary

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Official Symbol
Hyccinprovided by FlyBase
Official Full Name
hyccinprovided by FlyBase
Primary source
FLYBASE:FBgn0034269
Locus tag
Dmel_CG6406
See related
AllianceGenome:FB:FBgn0034269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6406; Dmel\CG6406; FAM126A; hyccin
Summary
Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Used to study hypomyelinating leukodystrophy 5. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 5. Orthologous to human HYCC1 (hyccin PI4KA lipid kinase complex subunit 1) and HYCC2 (hyccin PI4KA lipid kinase complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Hyccin in Genome Data Viewer
Location:
54E4-54E4; 2-84 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17734419..17737269, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13621924..13624774, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dachs ligand with SH3s Neighboring gene Sorting nexin 16 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class A Neighboring gene Vacuolar protein sorting 50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila. Sun M, et al. J Alzheimers Dis, 2018. PMID 30103315
  2. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila. Zhang Q, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34894559
  3. Genetic Dissection of Alzheimer's Disease Using Drosophila Models. Jeon Y, et al. Int J Mol Sci, 2020 Jan 30. PMID 32019113, Free PMC Article
  4. Behavioral screening of sleep-promoting effects of human intestinal and food-associated bacteria on Drosophila melanogaster. Ko T, et al. Genes Cells, 2023 Jun. PMID 36914986, Free PMC Article
  5. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIalpha in Drosophila.
    Title: Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hyccin
Names
CG6406-PA
CG6406-PB
Hyccin-PA
Hyccin-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17734419..17737269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166247.3 → NP_725714.1  hyccin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725714.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C5
    Related
    FBpp0086044
    Conserved Domains (1) summary
    pfam09790
    Location:20 → 346
    Hyccin; Hyccin

  2. NM_137412.4 → NP_611256.1  hyccin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1C5
    Related
    FBpp0086043
    Conserved Domains (1) summary
    pfam09790
    Location:20 → 346
    Hyccin; Hyccin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1C5 Q7K1C5

Gene LinkOut

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