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CG5033 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37036, updated on 9-Dec-2024

Summary

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Official Symbol
CG5033provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0028744
Locus tag
Dmel_CG5033
See related
AllianceGenome:FB:FBgn0028744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BOP1; Dmel\CG5033; dWDR36; EG:52C10.1
Summary
Predicted to enable ribonucleoprotein complex binding activity. Involved in regulation of hemocyte proliferation. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Is expressed in several structures, including embryonic/larval midgut primordium; head epidermis primordium; larval muscle cell; mesoderm; and visceral muscle primordium. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5033 in Genome Data Viewer
Location:
54E9-54E9; 2-84 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17789679..17792448)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13677184..13679953)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-31a stem loop Neighboring gene adrift Neighboring gene Ubiquitin conjugating enzyme 10 Neighboring gene antisense RNA:CR45270 Neighboring gene Double hit Neighboring gene grainy head

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Demontis F, et al. Cell Rep, 2014 Jun 12. PMID 24882005, Free PMC Article
  2. Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes. Hulf T, et al. Mol Cell Biol, 2005 May. PMID 15831447, Free PMC Article
  3. PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters. Gerlach JM, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078288, Free PMC Article
  4. The conserved Myc box 2 and Myc box 3 regions are important, but not essential, for Myc function in vivo. Schwinkendorf D, et al. Gene, 2009 May 1. PMID 19248823
  5. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Ebner A, et al. Gene, 2002 Apr 3. PMID 11992723

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5033-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17789679..17792448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137426.4 → NP_611270.1  uncharacterized protein Dmel_CG5033 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JQW4, Q7K0Y1
    Related
    FBpp0088519
    Conserved Domains (4) summary
    smart01035
    Location:171 → 436
    BOP1NT; BOP1NT (NUC169) domain
    COG2319
    Location:436 → 783
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:442 → 783
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:452 → 487
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K0Y1.1 Q7K0Y1

Gene LinkOut

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