Orai - orai
Enables store-operated calcium channel activity. Involved in calcium ion transport; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of calcium ion transport. Part of calcium channel complex. Is expressed in adult head; organism; wing hinge primordium; and wing pouch. Used to study dilated cardiomyopathy and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to several human genes including ORAI2 (ORAI calcium release-activated calcium modulator 2) and ORAI3 (ORAI calcium release-activated calcium modulator 3). [provided by Alliance of Genome Resources, Nov 2024]
NCBI Orthologs
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