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Elk Eag-like K[+] channel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37047, updated on 9-Dec-2024

Summary

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Official Symbol
Elkprovided by FlyBase
Official Full Name
Eag-like K[+] channelprovided by FlyBase
Primary source
FLYBASE:FBgn0011589
Locus tag
Dmel_CG5076
See related
AllianceGenome:FB:FBgn0011589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5076; dmELK; Dmel\CG5076; elk
Summary
Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in adult head and adult heart. Orthologous to human KCNH3 (potassium voltage-gated channel subfamily H member 3); KCNH4 (potassium voltage-gated channel subfamily H member 4); and KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Elk in Genome Data Viewer
Location:
54F4-55A2; 2-84 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17873939..17926695)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13761444..13814200)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44417 Neighboring gene uncharacterized protein Neighboring gene mapmodulin Neighboring gene three rows Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Prophenoloxidase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44418 Neighboring gene Protein phosphatase Y at 55A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels. Adaixo R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Sep 1. PMID 20823525, Free PMC Article
  2. Structural basis of two-stage voltage-dependent activation in K+ channels. Silverman WR, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12606713, Free PMC Article
  3. The eag family of K+ channels in Drosophila and mammals. Ganetzky B, et al. Ann N Y Acad Sci, 1999 Apr 30. PMID 10414305
  4. Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. Jegla T, et al. PLoS Genet, 2016 Dec. PMID 27911898, Free PMC Article
  5. A family of potassium channel genes related to eag in Drosophila and mammals. Warmke JW, et al. Proc Natl Acad Sci U S A, 1994 Apr 12. PMID 8159766, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. packing arrangement of protein molecules in the dmELK crystals was determined to belong to space group P4132, with two molecules in the asymmetric unit
    Title: Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables voltage-gated monoatomic cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in potassium ion transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Eag-like K[+] channel
Names
CG5076-PA
CG5076-PB
Elk-PA
Elk-PB
eag-like K+ channel
eag-like K[+] channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17873939..17926695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299624.1 → NP_001286553.1  Eag-like K[+] channel, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGW2, Q23974
    Conserved Domains (6) summary
    COG0664
    Location:582 → 649
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:585 → 714
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:36 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:280 → 515
    Ion_trans; Ion transport protein
    pfam07885
    Location:454 → 509
    Ion_trans_2; Ion channel
    pfam08447
    Location:41 → 129
    PAS_3; PAS fold

  2. NM_057661.3 → NP_477009.1  Eag-like K[+] channel, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477009.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB14, Q23974
    Related
    FBpp0085981
    Conserved Domains (6) summary
    COG0664
    Location:583 → 650
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:586 → 715
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:36 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:285 → 516
    Ion_trans; Ion transport protein
    pfam07885
    Location:455 → 510
    Ion_trans_2; Ion channel
    pfam08447
    Location:41 → 129
    PAS_3; PAS fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGW2 A0A0B4LGW2
A1ZB14 A1ZB14
Q23974 Q23974

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