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Naus Nausicaa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37076, updated on 9-Dec-2024

Summary

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Official Symbol
Nausprovided by FlyBase
Official Full Name
Nausicaaprovided by FlyBase
Primary source
FLYBASE:FBgn0034308
Locus tag
Dmel_CG10915
See related
AllianceGenome:FB:FBgn0034308
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10915; Dmel\CG10915; naus
Summary
Involved in actin filament bundle retrograde transport; positive regulation of cellular component organization; and protein localization to actin cytoskeleton. Located in lamellipodium and stress fiber. Part of FAR/SIN/STRIPAK complex. Is expressed in embryonic brain and organism. Orthologous to several human genes including CTTNBP2NL (CTTNBP2 N-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Naus in Genome Data Viewer
Location:
55B9-55B10; 2-84 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18160720..18164746)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14048225..14052251)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene lola like Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 75kD Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 9 Neighboring gene Dgp-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner. O'Connell ME, et al. Biol Open, 2019 Jun 17. PMID 31164339, Free PMC Article
  2. A conserved STRIPAK complex is required for autophagy in muscle tissue. Guo Y, et al. Mol Biol Cell, 2023 Aug 1. PMID 37379167, Free PMC Article
  3. Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling. Ribeiro PS, et al. Mol Cell, 2010 Aug 27. PMID 20797625
  4. Large-scale analysis of Drosophila core promoter function using synthetic promoters. Qi Z, et al. Mol Syst Biol, 2022 Feb. PMID 35156763, Free PMC Article
  5. Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division. Daeden A, et al. Nat Cell Biol, 2023 Feb. PMID 36747081, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in actin filament bundle retrograde transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lamellipodium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nausicaa
Names
CG10915-PA
CG10915-PB
Naus-PA
Naus-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18160720..18164746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299636.1 → NP_001286565.1  nausicaa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286565.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LFS3, Q8SX68, Q9V8D0
    Conserved Domains (2) summary
    pfam09727
    Location:78 → 274
    CortBP2; Cortactin-binding protein-2
    pfam12240
    Location:189 → 381
    Angiomotin_C; Angiomotin C terminal

  2. NM_137455.5 → NP_611299.2  nausicaa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611299.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LFS3, Q8SX68, Q9V8D0
    Related
    FBpp0085925
    Conserved Domains (2) summary
    pfam09727
    Location:78 → 274
    CortBP2; Cortactin-binding protein-2
    pfam12240
    Location:189 → 381
    Angiomotin_C; Angiomotin C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SX68.1 Q8SX68

Gene LinkOut

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