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GstE1 Glutathione S transferase E1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37106, updated on 4-Jan-2025

Summary

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Official Symbol
GstE1provided by FlyBase
Official Full Name
Glutathione S transferase E1provided by FlyBase
Primary source
FLYBASE:FBgn0034335
Locus tag
Dmel_CG5164
See related
AllianceGenome:FB:FBgn0034335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5164; CT16545; Dmel\CG5164; DmGST-3; DmGSTE1; DmGSTE1-1; gst-3; Gst-3; GST-3; GST-E1; Gst-theta 55F; Gst3; GST3; Gst55F; gste1; gstE1; GSTE1
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process and response to heat. Predicted to be located in cytoplasm. Is expressed in adult head; organism; stretch follicle cell; and unfertilized egg. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See GstE1 in Genome Data Viewer
Location:
55C6-55C6; 2-85 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18398393..18399223)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14285898..14286728)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Bomanin Short 6 Neighboring gene Imaginal disc growth factor 5 Neighboring gene Glutathione S transferase E10 Neighboring gene Glutathione S transferase E2 Neighboring gene Glutathione S transferase E3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a new theta-class glutathione-S-transferase (GST) gene, gst-3, from Drosophila melanogaster. Singh M, et al. Gene, 2000 Apr 18. PMID 10773456
  2. Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome. Li C, et al. Nat Commun, 2017 Nov 2. PMID 29097652, Free PMC Article
  3. Data on the expression of GSTE1 and GSTE7 in Drosophila chemosensory organs after isothiocyanate exposure. Fraichard S, et al. Data Brief, 2018 Oct. PMID 30148193, Free PMC Article
  4. Yin and Yang of mitochondrial ROS in Drosophila. Towarnicki SG, et al. J Insect Physiol, 2020 Apr. PMID 32045573
  5. Editor's Highlight: Glutathione S-Transferase Activity Moderates Methylmercury Toxicity During Development in Drosophila. Vorojeikina D, et al. Toxicol Sci, 2017 May 1. PMID 28184905, Free PMC Article

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S transferase E1
Names
CG5164-PA
Glutathione-S-transferase E1
GstE1-PA
glutathione S-transferase
glutathione-S-transferase
NP_611323.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18398393..18399223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137479.3 → NP_611323.1  glutathione S transferase E1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611323.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KK90
    Related
    FBpp0085850
    Conserved Domains (3) summary
    cd03177
    Location:94 → 210
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:8 → 197
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03045
    Location:6 → 79
    GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KK90 Q7KK90

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