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GstE6 Glutathione S transferase E6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37111, updated on 4-Jan-2025

Summary

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Official Symbol
GstE6provided by FlyBase
Official Full Name
Glutathione S transferase E6provided by FlyBase
Primary source
FLYBASE:FBgn0063494
Locus tag
Dmel_CG17530
See related
AllianceGenome:FB:FBgn0063494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17530; CT38747; Dmel\CG17530; DmGSTE6; E6; gste6; gstE6; GSTE6
Summary
Enables glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult heart; embryonic epipharynx; embryonic head epidermis; epithelium; and gut section. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See GstE6 in Genome Data Viewer
Location:
55C7-55C7; 2-85 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18406011..18406761)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14293516..14294266)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E4 Neighboring gene Glutathione S transferase E5 Neighboring gene Glutathione S transferase E7 Neighboring gene Glutathione S transferase E8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene. Tzafestas K, et al. New Phytol, 2017 Apr. PMID 27924627
  2. Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene. Mazari AMA, et al. Biochem Biophys Rep, 2016 Mar. PMID 28955816, Free PMC Article
  3. Glutathione transferases immobilized on nanoporous alumina: flow system kinetics, screening, and stability. Kjellander M, et al. Anal Biochem, 2014 Feb 1. PMID 24157647
  4. Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster. Scian M, et al. Acta Crystallogr D Biol Crystallogr, 2015 Oct. PMID 26457432, Free PMC Article
  5. Single amino-acid mutation in a Drosoph ila melanogaster ribosomal protein: An insight in uL11 transcriptional activity. Grunchec H, et al. PLoS One, 2022. PMID 35981051, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We report a new Epsilon class protein crystal structure from Drosophila melanogaster for the glutathione transferase DmGSTE6
    Title: Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site.
  2. The structures of two epsilon-class glutathione S-transferases from Drosophila, GSTE6 and GSTE7, are reported at 2.1 and 1.5 A resolution.
    Title: Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S transferase E6
Names
CG17530-PA
Glutathione-S-transferase E6
GstE6-PA
glutathione S-transferase
glutathione transferase E6
NP_611328.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18406011..18406761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137484.4 → NP_611328.1  glutathione S transferase E6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB71, Q7JZM3
    Related
    FBpp0085855
    Conserved Domains (2) summary
    cd03177
    Location:91 → 209
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    cd03045
    Location:4 → 77
    GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZB71 A1ZB71
Q7JZM3 Q7JZM3

Gene LinkOut

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