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Ttd14 TRPL translocation defect 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37119, updated on 9-Dec-2024

Summary

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Official Symbol
Ttd14provided by FlyBase
Official Full Name
TRPL translocation defect 14provided by FlyBase
Primary source
FLYBASE:FBgn0284257
Locus tag
Dmel_CG30118
See related
AllianceGenome:FB:FBgn0284257
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16859; CG30118; CG5544; Dmel\CG30118; l(2)08770; l(2)k04808; ttd14; TTD14
Summary
Enables GTP binding activity; phosphatidic acid binding activity; and phosphatidylinositol binding activity. Involved in cellular response to light stimulus; photoreceptor cell maintenance; and positive regulation of intracellular protein transport. Located in cytosol. Is expressed in several structures, including anlage in statu nascendi; endoderm anlage; gut section; larval muscle cell; and mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ttd14 in Genome Data Viewer
Location:
55C9-55C9; 2-85 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18430315..18440475, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14317820..14327980, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene immune deficiency Neighboring gene Dodeca-satellite-binding protein 1 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene scruin like at the midline Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene Pre-RNA processing factor 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. Cerny AC, et al. PLoS Genet, 2015 Oct. PMID 26509977, Free PMC Article
  2. Dissection of Complex, Fitness-Related Traits in Multiple Drosophila Mapping Populations Offers Insight into the Genetic Control of Stress Resistance. Everman ER, et al. Genetics, 2019 Apr. PMID 30760490, Free PMC Article
  3. Membrane protein trafficking in Drosophila photoreceptor cells. Schopf K, et al. Eur J Cell Biol, 2017 Aug. PMID 27964885
  4. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. Huang S, et al. PLoS Biol, 2013 Nov. PMID 24302888, Free PMC Article
  5. Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis. Milchanowski AB, et al. Genetics, 2004 Sep. PMID 15454546, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in photoreceptor cell maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
TRPL translocation defect 14
Names
CG30118-PA
CG30118-PB
CG30118-PC
Ttd14-PA
Ttd14-PB
Ttd14-PC
lethal (2) 08770

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18430315..18440475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103896.2 → NP_001097366.1  TRPL translocation defect 14, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097366.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYI2
    Conserved Domains (2) summary
    pfam13521
    Location:68 → 293
    AAA_28; AAA domain
    cl11964
    Location:323 → 481
    CYTH-like_Pase; CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases

  2. NM_001103895.2 → NP_001097365.1  TRPL translocation defect 14, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097365.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K556
    Conserved Domains (2) summary
    pfam13521
    Location:68 → 249
    AAA_28; AAA domain
    cl11964
    Location:279 → 437
    CYTH-like_Pase; CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases

  3. NM_137489.4 → NP_611333.1  TRPL translocation defect 14, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611333.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8DYI1, Q7K556
    Related
    FBpp0085903
    Conserved Domains (2) summary
    pfam13521
    Location:68 → 249
    AAA_28; AAA domain
    cl11964
    Location:279 → 437
    CYTH-like_Pase; CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DYI2 A8DYI2
Q7K556.1 Q7K556

Gene LinkOut

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