Lamtor2 Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lamtor2provided by FlyBase
Official Full Name: Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2provided by FlyBase
Primary source: FLYBASE:FBgn0034350
Locus tag: Dmel_CG5189
See related: AllianceGenome:FB:FBgn0034350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5189; Dmel\CG5189; dp14; p14
Summary: Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Part of Ragulator complex. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18446548..18449420)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14334053..14336925)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
contributes_to molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Ragulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ragulator complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of Ragulator complex	ISS Inferred from Sequence or Structural Similarity more info

Preferred Names: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

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The following sections contain reference sequences that belong to a specific genome build. Explain