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CG5493 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37139, updated on 4-Jan-2025

Summary

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Official Symbol
CG5493provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034364
Locus tag
Dmel_CG5493
See related
AllianceGenome:FB:FBgn0034364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5493
Summary
Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in L-cysteine catabolic process. Is expressed in embryonic ventral epidermis; embryonic/larval salivary gland; embryonic/larval salivary gland body; larval foregut atrium; and salivary gland body primordium. Orthologous to human CDO1 (cysteine dioxygenase type 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG5493 in Genome Data Viewer
Location:
55E2-55E2; 2-86 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18616692..18619328, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14504197..14506833, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 7 Neighboring gene uncharacterized protein Neighboring gene Secretory 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A toolkit for high-throughput, cross-species gene engineering in Drosophila. Ejsmont RK, et al. Nat Methods, 2009 Jun. PMID 19465918
  2. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
  3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
  4. Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. Shieh SY, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933837, Free PMC Article
  5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-cysteine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5493-PA
CG5493-PB
CG5493-PC
CG5493-PD
NP_001246409.1
NP_001246410.1
NP_001246411.1
NP_611348.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18616692..18619328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259480.2 → NP_001246409.1  uncharacterized protein Dmel_CG5493, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBA8, A8E780
    Conserved Domains (1) summary
    cl21464
    Location:29 → 212
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_001259482.2 → NP_001246411.1  uncharacterized protein Dmel_CG5493, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBA8, A8E780
    Conserved Domains (1) summary
    cl21464
    Location:29 → 212
    cupin_like; Conserved domain found in cupin and related proteins

  3. NM_001259481.2 → NP_001246410.1  uncharacterized protein Dmel_CG5493, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246410.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBA8, A8E780
    Conserved Domains (1) summary
    cl21464
    Location:29 → 212
    cupin_like; Conserved domain found in cupin and related proteins

  4. NM_137504.3 → NP_611348.1  uncharacterized protein Dmel_CG5493, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611348.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBA8, A8E780
    Related
    FBpp0085892
    Conserved Domains (1) summary
    cl21464
    Location:29 → 212
    cupin_like; Conserved domain found in cupin and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBA8 A1ZBA8

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