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Ntan1 N-terminal amidohydrolase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37147, updated on 4-Jan-2025

Summary

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Official Symbol
Ntan1provided by FlyBase
Official Full Name
N-terminal amidohydrolase 1provided by FlyBase
Primary source
FLYBASE:FBgn0034371
Locus tag
Dmel_CG5473
See related
AllianceGenome:FB:FBgn0034371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH24992; CG5473; dm-ntan1; Dmel\CG5473; ntan1; NTAN1; obek; SP2637
Summary
Enables protein-N-terminal asparagine amidohydrolase activity. Involved in negative regulation of glial cell proliferation; positive regulation of DNA endoreduplication; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Located in nucleus. Is expressed in several structures, including antennal lobe hub; embryonic epidermis; embryonic/larval optic lobe; first optic chiasma; and glial cell. Orthologous to human NTAN1 (N-terminal asparagine amidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Ntan1 in Genome Data Viewer
Location:
55E3-55E5; 2-86 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18640862..18658222, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14528367..14545727, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-GCC 1-9 Neighboring gene Chemosensory protein A 56a Neighboring gene uncharacterized protein Neighboring gene GDI interacting protein 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Ntan1 gene is expressed in perineural glia and neurons of adult Drosophila. Castañeda-Sampedro A, et al. Sci Rep, 2022 Aug 30. PMID 36042338, Free PMC Article
  2. Borderless regulates glial extension and axon ensheathment. Cameron S, et al. Dev Biol, 2016 Jun 15. PMID 27131624
  3. Organization of antennal lobe-associated neurons in adult Drosophila melanogaster brain. Tanaka NK, et al. J Comp Neurol, 2012 Dec 15. PMID 22592945
  4. A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis. Wang Z, et al. Elife, 2017 Dec 12. PMID 29231806, Free PMC Article
  5. Organization and metamorphosis of glia in the Drosophila visual system. Edwards TN, et al. J Comp Neurol, 2012 Jul 1. PMID 22351615

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In glia, Obek counteracts fibroblast growth factor and Hippo signaling to differentially affect cell growth and number.
    Title: Differential expression of Öbek controls ploidy in the Drosophila blood-brain barrier.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-N-terminal asparagine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-N-terminal asparagine amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-N-terminal asparagine amidohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-terminal amidohydrolase 1
Names
CG5473-PA
CG5473-PB
CG5473-PC
CG5473-PD
N-terminal amidohydrolase
Nt-amidase
Ntan1-PA
Ntan1-PB
Ntan1-PC
Ntan1-PD
SP2637
NP_001163199.1
NP_001163200.1
NP_611355.2
NP_725811.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18640862..18658222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169728.2 → NP_001163199.1  N-terminal amidohydrolase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KIS4
    Conserved Domains (1) summary
    pfam14736
    Location:40 → 306
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

  2. NM_001169729.2 → NP_001163200.1  N-terminal amidohydrolase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KIS4
    Conserved Domains (1) summary
    pfam14736
    Location:40 → 306
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

  3. NM_137511.4 → NP_611355.2  N-terminal amidohydrolase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611355.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSD1
    Related
    FBpp0085839
    Conserved Domains (1) summary
    pfam14736
    Location:40 → 306
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

  4. NM_166300.3 → NP_725811.1  N-terminal amidohydrolase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725811.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSD1
    Related
    FBpp0085840
    Conserved Domains (1) summary
    pfam14736
    Location:40 → 306
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KIS4 Q7KIS4
Q8MSD1 Q8MSD1

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