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Sik3 Salt-inducible kinase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37152, updated on 9-Dec-2024

Summary

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Official Symbol
Sik3provided by FlyBase
Official Full Name
Salt-inducible kinase 3provided by FlyBase
Primary source
FLYBASE:FBgn0262103
Locus tag
Dmel_CG42856
See related
AllianceGenome:FB:FBgn0262103
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15072; CG18604; CG42856; Dmel\CG42856; EMK/KIAA0999; SIK; SIK3
Old locus tag
Dmel_CG15072; Dmel_CG18604
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of hippo signaling; and negative regulation of triglyceride catabolic process. Is expressed in organism. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Sik3 in Genome Data Viewer
Location:
55E6-55E9; 2-86 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18688132..18705805)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14575637..14593310)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR33942 Neighboring gene Vacuolar protein sorting 51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila. Kobayashi R, et al. Front Neurosci, 2023. PMID 37662102, Free PMC Article
  2. SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons. Fujii S, et al. Proc Natl Acad Sci U S A, 2017 Aug 8. PMID 28743754, Free PMC Article
  3. LKB1 is physiologically required for sleep from Drosophila melanogaster to the Mus musculus. Liu Z, et al. Genetics, 2022 Jul 4. PMID 35579349, Free PMC Article
  4. Forward-genetics analysis of sleep in randomly mutagenized mice. Funato H, et al. Nature, 2016 Nov 17. PMID 27806374, Free PMC Article
  5. Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells. Zhang C, et al. J Cell Sci, 2021 Sep 1. PMID 34350957, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility.
    Title: SIK3 and Wnk converge on Fray to regulate glial K+ buffering and seizure susceptibility.
  2. SIK3 promotes the cytosolic localization of HDAC4, thereby relieving inhibition of Mef2-dependent transcription of K(+) and water transport molecules
    Title: SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K(+) and water.
  3. Study identifies Salt-inducible kinase 3 (SIK3), a member of the AMP-activated protein kinase (AMPK)-related kinase family, as a key determinant of Drosophila sugar tolerance.
    Title: Salt-Inducible Kinase 3 Provides Sugar Tolerance by Regulating NADPH/NADP(+) Redox Balance.
  4. SIK3-HDAC4 signaling in M cells regulates MSDR by regulating the molecular oscillation in DN1 neurons.
    Title: SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons.
  5. Drosophila salt-inducible kinases Sik2 and Sik3 are negative regulators of Hpo signalling.
    Title: Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Salt-inducible kinase 3
Names
CG42856-PA
CG42856-PB
CG42856-PC
CG42856-PD
CG42856-PE
CG42856-PF
Sik3-PA
Sik3-PB
Sik3-PC
Sik3-PD
Sik3-PE
Sik3-PF
NP_001097369.2
NP_001097370.2
NP_001188969.1
NP_001286587.1
NP_611359.1
NP_611361.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18688132..18705805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202040.1 → NP_001188969.1  Salt-inducible kinase 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188969.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBC4
    Conserved Domains (3) summary
    smart00220
    Location:41 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14338
    Location:335 → 380
    UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
    cl21453
    Location:40 → 292
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001299658.1 → NP_001286587.1  Salt-inducible kinase 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286587.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFW1
    Conserved Domains (3) summary
    smart00220
    Location:41 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14338
    Location:335 → 380
    UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
    cl21453
    Location:40 → 292
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001103900.2 → NP_001097370.2  Salt-inducible kinase 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097370.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYI5
    Conserved Domains (3) summary
    smart00220
    Location:41 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14338
    Location:335 → 380
    UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
    cl21453
    Location:40 → 292
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001103899.2 → NP_001097369.2  Salt-inducible kinase 3, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097369.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DYI4
    Conserved Domains (3) summary
    smart00220
    Location:41 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14338
    Location:335 → 380
    UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
    cl21453
    Location:40 → 292
    PKc_like; Protein Kinases, catalytic domain

  5. NM_137517.5 → NP_611361.4  Salt-inducible kinase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611361.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBC4
    Conserved Domains (3) summary
    smart00220
    Location:41 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14338
    Location:335 → 380
    UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
    cl21453
    Location:40 → 292
    PKc_like; Protein Kinases, catalytic domain

  6. NM_137515.3 → NP_611359.1  Salt-inducible kinase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611359.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QQA7
    Related
    FBpp0292993
    Conserved Domains (3) summary
    smart00220
    Location:41 → 292
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14338
    Location:335 → 380
    UBA_SIK; UBA domain found in salt-inducible kinase SIK1, SIK2, SIK3 and similar proteins
    cl21453
    Location:40 → 292
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFW1 A0A0B4LFW1
A1ZBC4 A1ZBC4
A8DYI4 A8DYI4
A8DYI5 A8DYI5
Q4QQA7 Q4QQA7
Q7K243 Q7K243

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