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CG15097 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37172, updated on 9-Dec-2024

Summary

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Official Symbol
CG15097provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034396
Locus tag
Dmel_CG15097
See related
AllianceGenome:FB:FBgn0034396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dm.CG15097; Dmel\CG15097
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in Bolwig organ; embryonic head sensory system; embryonic large intestine; ganglia; and sensory nervous system primordium. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG15097 in Genome Data Viewer
Location:
55F6-55F6; 2-86 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18822188..18829699, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14709693..14717204, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43418 Neighboring gene long non-coding RNA:CR46234 Neighboring gene Prohibitin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The BACK domain in BTB-kelch proteins. Stogios PJ, et al. Trends Biochem Sci, 2004 Dec. PMID 15544948
  2. Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. Kim LK, et al. PLoS Biol, 2007 Sep. PMID 17803358, Free PMC Article
  3. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. Cao C, et al. J Cell Biol, 2007 Mar 12. PMID 17339378, Free PMC Article
  4. Identification and investigation of Drosophila postsynaptic density homologs. Liebl FL, et al. Bioinform Biol Insights, 2008 Nov 3. PMID 19812789, Free PMC Article
  5. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG15097-PA
CG15097-PC
CG15097-PD
CG15097-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18822188..18829699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202044.2 → NP_001188973.1  uncharacterized protein Dmel_CG15097, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188973.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD92
    Conserved Domains (6) summary
    smart00612
    Location:417 → 463
    Kelch; Kelch domain
    PHA03098
    Location:65 → 539
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:359 → 402
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:63 → 166
    BTB; BTB/POZ domain
    pfam01344
    Location:499 → 543
    Kelch_1; Kelch motif
    pfam07707
    Location:174 → 276
    BACK; BTB And C-terminal Kelch

  2. NM_176232.3 → NP_788412.2  uncharacterized protein Dmel_CG15097, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788412.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBE3
    Conserved Domains (6) summary
    smart00612
    Location:417 → 463
    Kelch; Kelch domain
    PHA03098
    Location:65 → 539
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:359 → 402
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:63 → 166
    BTB; BTB/POZ domain
    pfam01344
    Location:499 → 543
    Kelch_1; Kelch motif
    pfam07707
    Location:174 → 276
    BACK; BTB And C-terminal Kelch

  3. NM_001274150.1 → NP_001261079.1  uncharacterized protein Dmel_CG15097, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261079.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEU3
    Conserved Domains (6) summary
    smart00612
    Location:417 → 463
    Kelch; Kelch domain
    PHA03098
    Location:65 → 539
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:359 → 402
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:63 → 166
    BTB; BTB/POZ domain
    pfam01344
    Location:499 → 543
    Kelch_1; Kelch motif
    pfam07707
    Location:174 → 276
    BACK; BTB And C-terminal Kelch

  4. NM_137533.4 → NP_611377.1  uncharacterized protein Dmel_CG15097, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K2Q6
    Related
    FBpp0085812
    Conserved Domains (5) summary
    smart00612
    Location:313 → 359
    Kelch; Kelch domain
    sd00038
    Location:255 → 298
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:9 → 62
    BTB; BTB/POZ domain
    pfam01344
    Location:395 → 439
    Kelch_1; Kelch motif
    pfam07707
    Location:70 → 172
    BACK; BTB And C-terminal Kelch
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD92 A0A0B4JD92
A0A0B4KEU3 A0A0B4KEU3
A1ZBE3 A1ZBE3
Q7K2Q6 Q7K2Q6
Q8IH99 Q8IH99

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