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hpo hippo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37247, updated on 9-Dec-2024

Summary

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Official Symbol
hpoprovided by FlyBase
Official Full Name
hippoprovided by FlyBase
Primary source
FLYBASE:FBgn0261456
Locus tag
Dmel_CG11228
See related
AllianceGenome:FB:FBgn0261456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11228; Dmel\CG11228; dMST; hipo; Hippo; Hpo; HPO; Hpo/Wts; MST; Mst1/2; MST2
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including eye morphogenesis; negative regulation of neurogenesis; and regulation of apoptotic process. Located in apicomedial cortex; cytosol; and membrane. Colocalizes with cell-cell junction. Is expressed in imaginal disc and organism. Used to study cancer; carcinoma; neurodegenerative disease; and obesity. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including STK3 (serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See hpo in Genome Data Viewer
Location:
56D13-56D13; 2-89 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19493996..19496856, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15381501..15384361, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene par-1 Neighboring gene Tubulin-binding cofactor B Neighboring gene Outer segment 6 Neighboring gene Rab escort protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hippo signaling pathway and organ size control. Zhang L, et al. Fly (Austin), 2009 Jan-Mar. PMID 19164949, Free PMC Article
  2. [Developmental control of organ growth by the Hippo pathway]. Bardet PL. Med Sci (Paris), 2009 Mar. PMID 19361388
  3. Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues. Weingartner KA, et al. Biochem J, 2023 Aug 16. PMID 37459121, Free PMC Article
  4. Hippo Signaling in the Heart　- Non-Canonical Pathways Impact Growth, Survival and Function. Del Re DP. Circ J, 2016 Jun 24. PMID 27296131
  5. Hippo unleashed! Proteome-scale analysis reveals new views of Hippo pathway biology. Weiss EL. Sci Signal, 2013 Nov 19. PMID 24255176

See all (587) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
    Title: Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia.
  2. The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
    Title: The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress.
  3. Combined inactivation of RB and Hippo converts differentiating Drosophila photoreceptors into eye progenitor cells through derepression of homothorax.
    Title: Combined inactivation of RB and Hippo converts differentiating Drosophila photoreceptors into eye progenitor cells through derepression of homothorax.
  4. Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
    Title: Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
  5. Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
    Title: Suppression of Patronin deficiency by altered Hippo signaling in Drosophila organ development.
  6. SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
    Title: SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
  7. Silence of yki by miR-7 regulates the Hippo pathway.
    Title: Silence of yki by miR-7 regulates the Hippo pathway.
  8. Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
    Title: Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
  9. Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.
    Title: Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.
  10. Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis.
    Title: Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (134)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in R8 cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippo signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in morphogenesis of an epithelial sheet IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organ growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein destabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apicomedial cortex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hippo
Names
CG11228-PA
CG11228-PB
HIPPO
MST
hippo kinase
hpo-PA
hpo-PB
NP_001261092.1
NP_611427.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19493996..19496856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274163.1 → NP_001261092.1  hippo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261092.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T0S6, Q9V8W4
    UniProtKB/TrEMBL
    A0A0B4KFW0
    Conserved Domains (3) summary
    cd06612
    Location:38 → 293
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:42 → 293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:608 → 655
    Mst1_SARAH; C terminal SARAH domain of Mst1

  2. NM_137583.5 → NP_611427.1  hippo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611427.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T0S6, Q9V8W4
    UniProtKB/TrEMBL
    A0A0B4KFW0
    Related
    FBpp0085688
    Conserved Domains (3) summary
    cd06612
    Location:38 → 293
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:42 → 293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:608 → 655
    Mst1_SARAH; C terminal SARAH domain of Mst1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFW0 A0A0B4KFW0
Q8T0S6.1 Q8T0S6

Gene LinkOut

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