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Kpc2 Kip1 ubiquitination-promoting complex subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37261, updated on 9-Dec-2024

Summary

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Official Symbol
Kpc2provided by FlyBase
Official Full Name
Kip1 ubiquitination-promoting complex subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0028372
Locus tag
Dmel_CG11025
See related
AllianceGenome:FB:FBgn0028372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11025; dKPC2; Dmel\CG11025; isopeptidase-T-3; Isopeptidase-T-3; IsoT-3; ISOT-3; ISOT-3A
Summary
Located in endoplasmic reticulum and sperm flagellum. Part of ubiquitin ligase complex. Is expressed in wing hinge primordium and wing pouch. Orthologous to human UBAC1 (UBA domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Kpc2 in Genome Data Viewer
Location:
56E1-56E1; 2-90 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19670618..19673477)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15558123..15560982)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hiiragi Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility. Li W, et al. PLoS Genet, 2020 Dec. PMID 33378371, Free PMC Article
  2. Non-Proteasomal UbL-UbA Family of Proteins in Neurodegeneration. Jantrapirom S, et al. Int J Mol Sci, 2019 Apr 17. PMID 30999567, Free PMC Article
  3. Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Zhou Z, et al. Dev Cell, 2015 Jul 6. PMID 26120032, Free PMC Article
  4. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
  5. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Kip1 ubiquitination-promoting complex subunit 2
Names
CG11025-PA
CG11025-PB
CG11025-PC
Kpc2-PA
Kpc2-PB
Kpc2-PC
isopeptidase T-3
isopeptidase-T-3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19670618..19673477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274169.2 → NP_001261098.1  Kip1 ubiquitination-promoting complex subunit 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261098.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFW5
    Conserved Domains (2) summary
    cd14304
    Location:434 → 472
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cl21463
    Location:345 → 384
    UBA_like_SF; UBA domain-like superfamily

  2. NM_137595.2 → NP_611439.2  Kip1 ubiquitination-promoting complex subunit 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611439.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86LF0
    Related
    FBpp0085669
    Conserved Domains (2) summary
    cd14304
    Location:430 → 468
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cl21463
    Location:341 → 380
    UBA_like_SF; UBA domain-like superfamily

  3. NM_166373.4 → NP_725921.1  Kip1 ubiquitination-promoting complex subunit 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBP3, Q8IHD7
    Related
    FBpp0085670
    Conserved Domains (2) summary
    cd14304
    Location:308 → 346
    UBA2_KPC2; UBA2 domain found in Kip1 ubiquitination-promoting complex protein 2 (KPC2) and similar proteins
    cl21463
    Location:219 → 258
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFW5 A0A0B4KFW5
A1ZBP3 A1ZBP3
Q86LF0 Q86LF0
Q8IHD7 Q8IHD7
Q9U904 Q9U904

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