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GNBP-like3 GNBP-like 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37313, updated on 4-Jan-2025

Summary

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Official Symbol
GNBP-like3provided by FlyBase
Official Full Name
GNBP-like 3provided by FlyBase
Primary source
FLYBASE:FBgn0034511
Locus tag
Dmel_CG13422
See related
AllianceGenome:FB:FBgn0034511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13422; Dmel\CG13422; GNBP-like; GNBPlike 3
Summary
Enables (1->3)-beta-D-glucan immune receptor activity and peptidoglycan binding activity. Involved in Toll receptor ligand protein activation cascade; antifungal innate immune response; and response to Gram-positive bacterium. Is active in extracellular space. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See GNBP-like3 in Genome Data Viewer
Location:
57A4-57A4; 2-91 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20526311..20526825)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16413816..16414330)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44650 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44651

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Contrasting evolutionary patterns in Drosophila immune receptors. Jiggins FM, et al. J Mol Evol, 2006 Dec. PMID 17103056, Free PMC Article
  2. Antimicrobial peptides modulate long-term memory. Barajas-Azpeleta R, et al. PLoS Genet, 2018 Oct. PMID 30312294, Free PMC Article
  3. Suppression of Drosophila antifungal immunity by a parasite effector via blocking GNBP3 and GNBP-like 3, the dual receptors for β-glucans. Lu M, et al. Cell Rep, 2024 Jan 23. PMID 38175756
  4. REL1, a homologue of Drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito Aedes aegypti. Shin SW, et al. J Biol Chem, 2005 Apr 22. PMID 15722339
  5. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Chamilos G, et al. Proc Natl Acad Sci U S A, 2008 Jul 8. PMID 18583479, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables (1->3)-beta-D-glucan immune receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptidoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll receptor ligand protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antifungal innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to other organism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of biotic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to fungus HEP PubMed 
involved_in response to fungus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GNBP-like 3
Names
CG13422-PA
GNBP-like
GNBP-like3-PA
Gram-negative binding protein-like protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20526311..20526825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137639.2 → NP_611483.1  GNBP-like 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611483.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ZX43, A1ZBU5
    Related
    FBpp0085532
    Conserved Domains (1) summary
    pfam15886
    Location:26 → 121
    CBM39; Carbohydrate binding domain (family 32)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBU5 A1ZBU5

Gene LinkOut

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