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Nnf1a Nnf1a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37325, updated on 9-Dec-2024

Summary

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Official Symbol
Nnf1aprovided by FlyBase
Official Full Name
Nnf1aprovided by FlyBase
Primary source
FLYBASE:FBgn0034523
Locus tag
Dmel_CG13434
See related
AllianceGenome:FB:FBgn0034523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13434; Dmel\CG13434; dmNnf1R-2
Summary
Enables kinetochore adaptor activity. Involved in attachment of spindle microtubules to kinetochore and mitotic metaphase chromosome alignment. Located in kinetochore. Part of MIS12/MIND type complex. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and nephrocyte. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nnf1a in Genome Data Viewer
Location:
57A6-57A6; 2-91 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20586222..20587238, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16473727..16474743, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-991 stem loop Neighboring gene mir-992 stem loop Neighboring gene Heterogeneous nuclear ribonucleoprotein K Neighboring gene mir-7 stem loop Neighboring gene Hillarin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Nnf1 paralogs are partially redundant for somatic and germ line kinetochore function. Blattner AC, et al. Chromosoma, 2017 Feb. PMID 26892014
  2. Network of protein interactions within the Drosophila inner kinetochore. Richter MM, et al. Open Biol, 2016 Feb. PMID 26911623, Free PMC Article
  3. Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster. Liu Y, et al. Open Biol, 2016 Feb. PMID 26911624, Free PMC Article
  4. Adaptive evolution of newly emerged micro-RNA genes in Drosophila. Lu J, et al. Mol Biol Evol, 2008 May. PMID 18296702, Free PMC Article
  5. Kinetochore Proteins Have a Post-Mitotic Function in Neurodevelopment. Zhao G, et al. Dev Cell, 2019 Mar 25. PMID 30827899, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kinetochore adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of MIS12/MIND type complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Nnf1a
Names
CG13434-PA
Nnf1-related protein 2
Nnf1a-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20586222..20587238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137648.4 → NP_611492.1  Nnf1a [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611492.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JZC9
    Related
    FBpp0085569
    Conserved Domains (1) summary
    PHA02562
    Location:124 → 194
    46; endonuclease subunit; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JZC9 Q7JZC9

Gene LinkOut

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