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Fem-1 Fem-1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37344, updated on 9-Dec-2024

Summary

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Official Symbol
Fem-1provided by FlyBase
Official Full Name
Fem-1provided by FlyBase
Primary source
FLYBASE:FBgn0034542
Locus tag
Dmel_CG9025
See related
AllianceGenome:FB:FBgn0034542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9025; dFEM-1; dFEM1B; Dmel\CG9025
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of ubiquitin-protein transferase activity. Predicted to be part of ubiquitin ligase complex. Is expressed in spermatozoon. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Fem-1 in Genome Data Viewer
Location:
57A9-57A9; 2-91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20662474..20667306, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16549979..16554811, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Leucine-rich tendon-specific protein Neighboring gene transfer RNA:Tryptophan-CCA 1-1 Neighboring gene transfer RNA:Tryptophan-CCA 1-2 Neighboring gene uncharacterized protein Neighboring gene exuperantia Neighboring gene galla-1 Neighboring gene Gustatory receptor 57a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Accumulation of Spock and Worf, two novel non-LTR retrotransposons, on the neo-Y chromosome of Drosophila miranda. Bachtrog D. Mol Biol Evol, 2003 Feb. PMID 12598683
  2. On the genomic location of the exuperantia1 gene in Drosophila miranda: the limits of in situ hybridization experiments. Bachtrog D, et al. Genetics, 2003 Jul. PMID 12871928, Free PMC Article
  3. Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Sattelle DB, et al. Bioessays, 2005 Apr. PMID 15770687
  4. FEM1 proteins are ancient regulators of SLBP degradation. Dankert JF, et al. Cell Cycle, 2017 Mar 19. PMID 28118078, Free PMC Article
  5. Protein evolution and codon usage bias on the neo-sex chromosomes of Drosophila miranda. Bachtrog D. Genetics, 2003 Nov. PMID 14668377, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fem-1
Names
CG9025-PA
CG9025-PB
Fem-1-PA
Fem-1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20662474..20667306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137664.3 → NP_611508.1  Fem-1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611508.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUF6
    Related
    FBpp0085558
    Conserved Domains (4) summary
    cd00204
    Location:142 → 262
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:180 → 266
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:244 → 294
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:178 → 206
    ANK; ANK repeat [structural motif]

  2. NM_166408.2 → NP_725993.1  Fem-1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZBY0, A1ZBY1, Q8IGM5, Q8MS72
    Related
    FBpp0085559
    Conserved Domains (4) summary
    cd00204
    Location:90 → 210
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:128 → 214
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:192 → 242
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:126 → 154
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBY1.1 A1ZBY1

Gene LinkOut

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