nkx2-2.S NK2 homeobox 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nkx2-2.S
Official Full Name: NK2 homeobox 2 S homeolog
Primary source: Xenbase:XB-GENE-864842
Locus tag: XELAEV_18028840mg
See related: EnsemblRapid:ENSXLAG00005024489 AllianceGenome:Xenbase:XB-GENE-864842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: XeNK-2; nkx2-2; nkx2.2; Xnkx2.2; nkx2-2-A
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in ectoderm; nervous system; and visual system. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 5S

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (28429005..28431607)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (28512148..28514762)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein XENK-2

Names: NK2 transcription factor related, locus 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085622.1 → NP_001079091.1 homeobox protein XENK-2

See identical proteins and their annotated locations for NP_001079091.1

Status: PROVISIONAL

Source sequence(s)

L10327

UniProtKB/Swiss-Prot

P42587

Conserved Domains (2) summary

pfam00046
Location:72 → 125

Homeobox; Homeobox domain

cl03757
Location:17 → 47

phosphohexomutase; The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine ...