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otp orthopedia [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37364, updated on 9-Dec-2024

Summary

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Official Symbol
otpprovided by FlyBase
Official Full Name
orthopediaprovided by FlyBase
Primary source
FLYBASE:FBgn0015524
Locus tag
Dmel_CG10036
See related
AllianceGenome:FB:FBgn0015524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE58095; bk24; CG10036; CG2965; Dmel\CG10036; Otp; w26; W26
Summary
Enables DNA binding activity. Predicted to be involved in neuron differentiation. Is expressed in several structures, including anal pad; central brain primordium; embryonic brain; gut section; and ventral nerve cord. Orthologous to human OTP (orthopedia homeobox). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See otp in Genome Data Viewer
Location:
57B4-57B4; 2-92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20883625..20903414, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16771130..16790919, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Inositol phosphate kinase 1 Neighboring gene Calcium and integrin binding family member 2 Neighboring gene antisense RNA:CR43160 Neighboring gene Carbonic anhydrase 15 Neighboring gene Retinal Homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of Otx and Otp genes in brain development. Acampora D, et al. Int J Dev Biol, 2000. PMID 11061431
  2. When Brachyury meets Smad1: the evolution of bilateral symmetry during gastrulation. Marcellini S. Bioessays, 2006 Apr. PMID 16547957
  3. Orthopedia expression during Drosophila melanogaster nervous system development and its regulation by microRNA-252. Hildebrandt K, et al. Dev Biol, 2022 Dec. PMID 36179878
  4. The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut. Hildebrandt K, et al. Hereditas, 2020 Nov 19. PMID 33213520, Free PMC Article
  5. Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development. Eggert T, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482887, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brachyenteron activates the homeobox gene orthopedia.
    Title: Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
orthopedia
Names
CG10036-PC
CG10036-PE
CG10036-PF
CG10036-PG
CG10036-PH
CG10036-PI
CG10036-PJ
CG10036-PK
CG10036-PL
otp-PC
otp-PE
otp-PF
otp-PG
otp-PH
otp-PI
otp-PJ
otp-PK
otp-PL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20883625..20903414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001369956.1 → NP_001356966.1  orthopedia, isoform L [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4P7VNY3
    Conserved Domains (1) summary
    pfam00046
    Location:112 → 161
    Homeobox; Homeobox domain

  2. NM_001299723.1 → NP_001286652.1  orthopedia, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG13
    Conserved Domains (1) summary
    pfam00046
    Location:112 → 160
    Homeobox; Homeobox domain

  3. NM_001103918.3 → NP_001097388.2  orthopedia, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097388.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4IJ64, P56672, Q3KN52, Q7KVQ3, Q9W2Q4
    Conserved Domains (1) summary
    pfam00046
    Location:112 → 160
    Homeobox; Homeobox domain

  4. NM_001299724.1 → NP_001286653.1  orthopedia, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LG58
    Conserved Domains (1) summary
    pfam00046
    Location:119 → 167
    Homeobox; Homeobox domain

  5. NM_001299725.1 → NP_001286654.1  orthopedia, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286654.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH19
    Conserved Domains (1) summary
    pfam00046
    Location:119 → 167
    Homeobox; Homeobox domain

  6. NM_079075.5 → NP_523799.3  orthopedia, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523799.3

    Status: REVIEWED

    Related
    FBpp0309633
    Conserved Domains (1) summary
    pfam00046
    Location:9 → 57
    Homeobox; Homeobox domain

  7. NM_001299722.1 → NP_001286651.1  orthopedia, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFU7
    Conserved Domains (1) summary
    pfam00046
    Location:9 → 57
    Homeobox; Homeobox domain

  8. NM_001043098.2 → NP_001036563.1  orthopedia, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036563.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P56672
    Conserved Domains (1) summary
    pfam00046
    Location:16 → 64
    Homeobox; Homeobox domain

  9. NM_001299721.1 → NP_001286650.1  orthopedia, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286650.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFZ2
    Conserved Domains (1) summary
    pfam00046
    Location:16 → 65
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFU7 A0A0B4LFU7
A0A0B4LFZ2 A0A0B4LFZ2
A0A0B4LG13 A0A0B4LG13
A0A0B4LG58 A0A0B4LG58
A0A0B4LH19 A0A0B4LH19
A0A4P7VNY3 A0A4P7VNY3
P56672.2 P56672
Q8SYH5 Q8SYH5

Gene LinkOut

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