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cpa capping protein alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37387, updated on 18-Sep-2024

Summary

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Official Symbol
cpaprovided by FlyBase
Official Full Name
capping protein alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0034577
Locus tag
Dmel_CG10540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cap1; CapZalpha; CG10540; Cp&abg;; Cpa; CpA; cpalpha; Dmel\CG10540; miro; scrd
Orthologs
all
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Genomic context

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See cpa in Genome Data Viewer
Location:
57B16-57B16; 2-92 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21057787..21059883)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16945292..16947388)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45148 Neighboring gene shotgun Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 8 Neighboring gene Chitinase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels. Amândio AR, et al. PLoS One, 2014. PMID 24788460, Free PMC Article
  2. Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Gates J, et al. Dev Biol, 2009 Sep 1. PMID 19576200, Free PMC Article
  3. Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene. Fernández BG, et al. Oncogene, 2014 Apr 17. PMID 23644660
  4. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. Sansores-Garcia L, et al. EMBO J, 2011 May 10. PMID 21556047, Free PMC Article
  5. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Fernández BG, et al. Development, 2011 Jun. PMID 21525075

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that actin-capping protein subunits Cpa and Cpb stabilize each other's protein levels and can stimulate the production of each other's mRNA when the level of one of the subunit is reduced.
    Title: Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.
  2. Data show that the actin-Capping Protein (CP) alphabeta heterodimer, which regulates actin filament (F-actin) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK activation.
    Title: Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.
  3. findings show an interdependency between Hpo signaling activity and F-actin dynamics in which CP and Hpo pathway activities inhibit F-actin accumulation, and the reduction in F-actin in turn sustains Hpo pathway activity
    Title: Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila.
  4. Enabled and Capping actin regulator proteins shape oogenesis.
    Title: Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.
  5. Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium
    Title: Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of F-actin capping protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
capping protein alpha
Names
CG10540-PA
actin capping protein
actin-capping protein
capping alpha
capping protein
capping protein A
capping proteinalpha
cpa-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21057787..21059883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137695.4 → NP_611539.1  capping protein alpha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611539.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W2N0
    Related
    FBpp0071461
    Conserved Domains (1) summary
    pfam01267
    Location:15 → 284
    F-actin_cap_A; F-actin capping protein alpha subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2N0.1 Q9W2N0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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