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gabbr1a gamma-aminobutyric acid (GABA) B receptor, 1a [ Danio rerio (zebrafish) ]

Gene ID: 373873, updated on 4-Jan-2025

Summary

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Official Symbol
gabbr1aprovided by ZNC
Official Full Name
gamma-aminobutyric acid (GABA) B receptor, 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030904-5
See related
Ensembl:ENSDARG00000018967 AllianceGenome:ZFIN:ZDB-GENE-030904-5
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gabbr1
Summary
Predicted to enable G protein-coupled GABA receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See gabbr1a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34716067..34845339, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34858513..34987677, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene lymphotoxin alpha (TNF superfamily, member 1) Neighboring gene tumor necrosis factor b (TNF superfamily, member 2) Neighboring gene SH3-binding domain protein 5-like, a Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway. Zaupa M, et al. Curr Biol, 2021 Nov 8. PMID 34529937, Free PMC Article
  2. Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning. Baker MR, et al. Sci Rep, 2021 Jun 8. PMID 34103598, Free PMC Article
  3. Immunohistochemical localization of GABA, GAD65, and the receptor subunits GABAAalpha1 and GABAB1 in the zebrafish cerebellum. Delgado L, et al. Cerebellum, 2008. PMID 18633686
  4. Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish. Allen JR, et al. Genetics, 2019 Oct. PMID 31444245, Free PMC Article
  5. Multiplexed Genome Editing for Efficient Phenotypic Screening in Zebrafish. Guo S, et al. Vet Sci, 2022 Feb 19. PMID 35202345, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled GABA receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid type B receptor subunit 1
Names
gaba1
gamma-aminobutyric acid (GABA) B receptor, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    34716067..34845339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_689405.9 → XP_694497.5  gamma-aminobutyric acid type B receptor subunit 1

    UniProtKB/TrEMBL
    A0A8N7UVF8
    Related
    ENSDARP00000004577.7, ENSDART00000009892.8
    Conserved Domains (5) summary
    cd06366
    Location:168 → 561
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    smart00032
    Location:98 → 155
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    pfam00003
    Location:601 → 855
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:184 → 541
    ANF_receptor; Receptor family ligand binding region
    pfam10211
    Location:883 → 925
    Ax_dynein_light; Axonemal dynein light chain
Nucleotide Protein
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