PFKM phosphofructokinase, muscle [Gallus gallus (chicken)] - Gene

Summary

Symbol: PFKMprovided by CGNC
Full Name: phosphofructokinase, muscleprovided by CGNC
Primary source: CGNC:10017
See related: Ensembl:ENSGALG00010024547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 34

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	34	NC_052565.1 (1166793..1174134)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	34	NC_052606.1 (1126096..1133434)

Chromosome 34 - NC_052565.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PFK-M and PFK-L regulate the glycolytic pathway in the insulin-stimulated state of skeletal muscles and, therefore, glucose metabolism in chicken skeletal muscle may be regulated in a very different manner compared to mammals.
Title: Two types of phosphofructokinase-1 differentially regulate the glycolytic pathway in insulin-stimulated chicken skeletal muscle.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 6-phosphofructokinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables AMP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables fructose-6-phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables monosaccharide binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fructose 1,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in fructose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of 6-phosphofructokinase complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ATP-dependent 6-phosphofructokinase, muscle type

Names: 6-phosphofructokinase, muscle type

NP_989554.3

EC 2.7.1.11

XP_046760898.1

EC 2.7.1.11

XP_046790130.1

EC 2.7.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204223.2 → NP_989554.3 ATP-dependent 6-phosphofructokinase, muscle type

Status: VALIDATED

Source sequence(s)

AB061205, BU309531, CO503451, CO503521, CO504745

UniProtKB/TrEMBL

Q90YA3

Related

ENSGALP00010036637.1, ENSGALT00010059877.1

Conserved Domains (2) summary

cd00764
Location:15 → 775

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

TIGR02478
Location:18 → 756

6PF1K_euk; 6-phosphofructokinase, eukaryotic type