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Hmg-2 High mobility group protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37407, updated on 9-Dec-2024

Summary

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Official Symbol
Hmg-2provided by FlyBase
Official Full Name
High mobility group protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0026582
Locus tag
Dmel_CG9418
See related
AllianceGenome:FB:FBgn0026582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD07122; CG9418; Dmel\CG9418; LD07122
Summary
Predicted to be involved in regulation of gene expression. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human HMG20A (high mobility group 20A) and HMG20B (high mobility group 20B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Hmg-2 in Genome Data Viewer
Location:
57C4-57C4; 2-93 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21146203..21147608)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17033708..17035113)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene X box binding protein-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tryptophan-CCA 2-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. Pirooznia SK, et al. PLoS One, 2012. PMID 22848598, Free PMC Article
  2. The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F. Bugga L, et al. Mol Cell Biol, 2009 Jun. PMID 19332563, Free PMC Article
  3. Identification of novel Drosophila centromere-associated proteins. Barth TK, et al. Proteomics, 2014 Oct. PMID 24841622
  4. Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. Coelho DS, et al. Cell Rep, 2013 Nov 14. PMID 24183663, Free PMC Article
  5. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
high mobility group protein 2
Names
CG9418-PA
Hmg-2-PA
high mobility group protein 1/2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21146203..21147608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137709.4 → NP_611553.1  high mobility group protein 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2K8
    Related
    FBpp0071501
    Conserved Domains (1) summary
    cd01390
    Location:76 → 141
    HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2K8 Q9W2K8

Gene LinkOut

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