CRY2 cryptochrome circadian regulator 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CRY2provided by CGNC
Full Name: cryptochrome circadian regulator 2provided by CGNC
Primary source: CGNC:6396
See related: Ensembl:ENSGALG00010022046
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: gCry2
Summary: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (23477156..23497481, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (23444728..23465083, complement)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

light-sensitive clock components in the pinealocytes may be involved in the repression of Cry2 transcription at night, which may contribute to resetting the phase of the clock within 24 h
Title: Expression of Cry2 in the chicken pineal gland: effects of changes in light-dark conditions.
data characterize a non-opsin photoreception mechanism in the chick iris and suggest a conserved photoreceptive role for cryptochromes in vertebrates
Title: Nonvisual photoreception in the chick iris.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables FAD binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cryptochrome-2

Names: cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204244.2 → NP_989575.1 cryptochrome-2

See identical proteins and their annotated locations for NP_989575.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000214

UniProtKB/TrEMBL

A0A8V0ZNA3

Related

ENSGALP00010032300.1, ENSGALT00010053614.1

Conserved Domains (3) summary

COG0415
Location:14 → 500

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam00875
Location:14 → 162

DNA_photolyase; DNA photolyase

pfam03441
Location:222 → 495

FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

23477156..23497481 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015286915.4 → XP_015142401.2 cryptochrome-2 isoform X1

UniProtKB/TrEMBL

A0A8V0ZNA3

Conserved Domains (1) summary

COG0415
Location:14 → 500

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

23444728..23465083 complement

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GenBank, FASTA, Sequence Viewer (Graphics)