ACVR2B activin A receptor type 2B [Gallus gallus (chicken)] - Gene

Summary

Symbol: ACVR2Bprovided by CGNC
Full Name: activin A receptor type 2Bprovided by CGNC
Primary source: CGNC:4620
See related: Ensembl:ENSGALG00010027103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ActRIIB; ACTR-IIB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (5716617..5842556, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (5721740..5841353, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
Title: Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken.
and formed a sub cluster with in avian cluster. The current research provides insights about structural and functional aspects of the receptor and also aids in understanding the evolutionary history of ACTRIIB.
Title: Molecular characterization and computational structure prediction of activin receptor type IIB in aseel and broiler chicken.
This study demonstrated that the role of ACVR2B expression in ciliary ganglion neuronal development, investigating its function in neuronal differentiation and ontogenetic cell death.
Title: Signaling via the transcriptionally regulated activin receptor 2B is a novel mediator of neuronal cell death during chicken ciliary ganglion development.

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General gene information

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Markers

MCW0341 (e-PCR), detects polymorphism
- UniSTS:280189

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables activin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables activin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of activin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: activin receptor type-2B

Names: activin A receptor, type IIB; activin receptor type 2B; activin receptor type IIB

NP_989648.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204317.2 → NP_989648.1 activin receptor type-2B precursor

See identical proteins and their annotated locations for NP_989648.1

Status: VALIDATED

Source sequence(s)

JAENSK010000035

UniProtKB/Swiss-Prot

Q90670

UniProtKB/TrEMBL

A0A1Z1XG81, A0A1Z1XG83

Related

ENSGALP00010039953.1, ENSGALT00010065687.1

Conserved Domains (3) summary

smart00220
Location:198 → 471

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14140
Location:194 → 484

STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor

pfam01064
Location:39 → 117

Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

5716617..5842556 complement

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GenBank, FASTA, Sequence Viewer (Graphics)