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eEFSec eukaryotic translation elongation factor, selenocysteine-specific [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37444, updated on 4-Jan-2025

Summary

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Official Symbol
eEFSecprovided by FlyBase
Official Full Name
eukaryotic translation elongation factor, selenocysteine-specificprovided by FlyBase
Primary source
FLYBASE:FBgn0034627
Locus tag
Dmel_CG9841
See related
AllianceGenome:FB:FBgn0034627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9841; deEFsec; dEFsec; Dmel\CG9841; eEFsec; Efsec; EfSec; EFsec; EFSec; Eftu; SelB/eEFsec
Summary
Enables GTPase activating protein binding activity. Involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See eEFSec in Genome Data Viewer
Location:
57E1-57E1; 2-95 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21384552..21386221, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17272057..17273726, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene crossveinless 2 Neighboring gene acyl-Coenzyme A oxidase at 57D proximal Neighboring gene acyl-Coenzyme A oxidase at 57D distal Neighboring gene biscotti Neighboring gene Syndecan

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Decoding apparatus for eukaryotic selenocysteine insertion. Tujebajeva RM, et al. EMBO Rep, 2000 Aug. PMID 11265756, Free PMC Article
  2. Conserved selenoprotein synthesis is not critical for oxidative stress defence and the lifespan of Drosophila. Hirosawa-Takamori M, et al. EMBO Rep, 2004 Mar. PMID 14978508, Free PMC Article
  3. Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance. Shchedrina VA, et al. J Biol Chem, 2011 Aug 26. PMID 21622567, Free PMC Article
  4. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Lobanov AV, et al. Protein Sci, 2008 Jan. PMID 18156471, Free PMC Article
  5. A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. Hirosawa-Takamori M, et al. FASEB J, 2009 Jan. PMID 18772345, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila mutants that lack the translation elongation factor SelB/eEFsec fail to decode the UGA codon as selenocysteine, but they are viable and fertile.
    Title: Conserved selenoprotein synthesis is not critical for oxidative stress defence and the lifespan of Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in selenocysteine incorporation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in selenocysteine incorporation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational readthrough IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation elongation factor, selenocysteine-specific
Names
CG9841-PA
EfSec
eEFSec-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21384552..21386221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137740.3 → NP_611584.1  eukaryotic translation elongation factor, selenocysteine-specific [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611584.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2H0
    Related
    FBpp0071534
    Conserved Domains (4) summary
    cd01889
    Location:5 → 192
    SelB_euk; SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome
    COG3276
    Location:6 → 467
    SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
    cd03696
    Location:196 → 278
    SelB_II; Domain II of elongation factor SelB
    cd04094
    Location:283 → 396
    eSelB_III; Domain III of eukaryotic and archaeal elongation factor SelB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2H0 Q9W2H0

Gene LinkOut

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