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MESK2 Misexpression suppressor of KSR 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37451, updated on 9-Dec-2024

Summary

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Official Symbol
MESK2provided by FlyBase
Official Full Name
Misexpression suppressor of KSR 2provided by FlyBase
Primary source
FLYBASE:FBgn0043070
Locus tag
Dmel_CG15669
See related
AllianceGenome:FB:FBgn0043070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH12032; BcDNA:LD27504; BcDNA:RH10174; CG15668; CG15669; Dmel\CG15669; l(2)01467; mesk2; Mesk2
Summary
Enables serine hydrolase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in adult head; wing hinge primordium; and wing pouch. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to several human genes including NDRG1 (N-myc downstream regulated 1); NDRG2 (NDRG family member 2); and NDRG3 (NDRG family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MESK2 in Genome Data Viewer
Location:
57E8-57E9; 2-95 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21502097..21517241)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17389602..17404746)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit C-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genetic basis of variation in Drosophila melanogaster mating behavior. Yamamoto A, et al. iScience, 2024 May 17. PMID 38766354, Free PMC Article
  2. An efficient promoter trap for detection of patterned gene expression and subsequent functional analysis in Drosophila. Larsen C, et al. Proc Natl Acad Sci U S A, 2006 Nov 21. PMID 17093046, Free PMC Article
  3. Micro RNAs and the biological clock: a target for diseases associated with a loss of circadian regulation. Ma Q, et al. Afr Health Sci, 2020 Dec. PMID 34394254, Free PMC Article
  4. Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs. Han SK, et al. Nat Commun, 2023 Apr 19. PMID 37076491, Free PMC Article
  5. A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Huang AM, et al. Genetics, 2000 Nov. PMID 11063696, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
misexpression suppressor of KSR 2
Names
CG15669-PA
CG15669-PB
CG15669-PC
CG15669-PD
CG15669-PE
CG15669-PF
CG15669-PI
CG15669-PJ
CG15669-PK
MESK2-PA
MESK2-PB
MESK2-PC
MESK2-PD
MESK2-PE
MESK2-PF
MESK2-PI
MESK2-PJ
MESK2-PK

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21502097..21517241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206192.2 → NP_995914.1  misexpression suppressor of KSR 2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GU50
    Conserved Domains (2) summary
    COG0596
    Location:57 → 334
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:51 → 337
    Abhydrolase; alpha/beta hydrolases

  2. NM_206193.2 → NP_995915.1  misexpression suppressor of KSR 2, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995915.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGI1
    Conserved Domains (2) summary
    COG0596
    Location:40 → 317
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:34 → 320
    Abhydrolase; alpha/beta hydrolases

  3. NM_166454.2 → NP_726076.1  misexpression suppressor of KSR 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726076.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q8T0V2
    Related
    FBpp0088650
    Conserved Domains (2) summary
    COG0596
    Location:139 → 416
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases

  4. NM_206190.2 → NP_995912.1  misexpression suppressor of KSR 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995912.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q8T0V2
    Conserved Domains (2) summary
    COG0596
    Location:139 → 416
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases

  5. NM_079080.3 → NP_523804.3  misexpression suppressor of KSR 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523804.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRK7
    Related
    FBpp0088652
    Conserved Domains (2) summary
    COG0596
    Location:57 → 334
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:51 → 337
    Abhydrolase; alpha/beta hydrolases

  6. NM_166455.2 → NP_726077.1  misexpression suppressor of KSR 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726077.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q9I7V7
    Related
    FBpp0088649
    Conserved Domains (1) summary
    cl21494
    Location:133 → 421
    Abhydrolase; alpha/beta hydrolases

  7. NM_166456.3 → NP_726078.1  misexpression suppressor of KSR 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726078.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q9I7V6
    Related
    FBpp0088651
    Conserved Domains (1) summary
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases

  8. NM_206194.2 → NP_995916.1  misexpression suppressor of KSR 2, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KVN1, Q8IHC7
    Conserved Domains (1) summary
    cl21494
    Location:105 → 391
    Abhydrolase; alpha/beta hydrolases

  9. NM_206191.2 → NP_995913.1  misexpression suppressor of KSR 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995913.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHG2, Q8T0V2
    Conserved Domains (2) summary
    COG0596
    Location:139 → 416
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    cl21494
    Location:133 → 419
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KVN1 Q7KVN1
Q8IGI1 Q8IGI1
Q8IH54 Q8IH54
Q8IHC7 Q8IHC7
Q8IHG2 Q8IHG2
Q8IHH2 Q8IHH2
Q8IRK7 Q8IRK7
Q8SYA3 Q8SYA3
Q8T0V2 Q8T0V2
Q95T14 Q95T14
Q9GU49 Q9GU49
Q9GU50 Q9GU50
Q9I7V6 Q9I7V6
Q9I7V7 Q9I7V7

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