mahj mahjong [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mahjprovided by FlyBase
Official Full Name: mahjongprovided by FlyBase
Primary source: FLYBASE:FBgn0034641
Locus tag: Dmel_CG10080
See related: AllianceGenome:FB:FBgn0034641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.151; BcDNA:SD08722; CG10080; Dmel\CG10080; Mahj; VprBP
Summary: Involved in cell competition in a multicellular organism. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in spermatozoon. Orthologous to human DCAF1 (DDB1 and CUL4 associated factor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 57F4-57F5; 2-96 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21625030..21631422)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17512535..17518927)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate that Mahjong interacts with Lgl biochemically and genetically and that Mahjong and Lgl function in the same pathway to regulate cellular competitiveness.[Mahjong]
Title: Involvement of Lgl and Mahjong/VprBP in cell competition.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mahjong

Names: CG10080-PA; CG10080-PB; mahj-PA; mahj-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21625030..21631422

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259522.2 → NP_001246451.1 mahjong, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246451.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5U167, Q86PE6, Q8MT13, Q9W2F2

UniProtKB/TrEMBL

A0A0B4K8A5

Conserved Domains (4) summary

smart00667
Location:912 → 944

LisH; Lissencephaly type-1-like homology motif

COG2319
Location:1194 → 1423

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1159 → 1192

7WD40; WD40 repeat [structural motif]

cl02567
Location:1159 → 1350

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_137748.4 → NP_611592.2 mahjong, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611592.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5U167, Q86PE6, Q8MT13, Q9W2F2

UniProtKB/TrEMBL

A0A0B4K8A5

Related

FBpp0071575

Conserved Domains (4) summary

smart00667
Location:912 → 944

LisH; Lissencephaly type-1-like homology motif

COG2319
Location:1194 → 1423

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1159 → 1192

7WD40; WD40 repeat [structural motif]

cl02567
Location:1159 → 1350

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...