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stum stumble [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37473, updated on 9-Dec-2024

Summary

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Official Symbol
stumprovided by FlyBase
Official Full Name
stumbleprovided by FlyBase
Primary source
FLYBASE:FBgn0050263
Locus tag
Dmel_CG30263
See related
AllianceGenome:FB:FBgn0050263
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15677; CG15679; CG30263; CT35864; Dmel\CG30263; mdcds_15969
Summary
Involved in proprioception; sensory perception of mechanical stimulus; and taxis. Located in sensory dendrite. Is expressed in adult leg stretch receptor neurons; adult ventral nerve cord; and leg. Orthologous to human STUM (stum, mechanosensory transduction mediator homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See stum in Genome Data Viewer
Location:
57F8-57F8; 2-96 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21674901..21685000)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17562406..17572505)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Negative Cofactor 2alpha Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit k Neighboring gene TATA binding protein Neighboring gene Baramicin C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GABAergic inhibition of leg motoneurons is required for normal walking behavior in freely moving Drosophila. Gowda SBM, et al. Proc Natl Acad Sci U S A, 2018 Feb 27. PMID 29440493, Free PMC Article
  2. NOMPC-dependent mechanotransduction shapes the dendrite of proprioceptive neurons. Chadha A, et al. Neurosci Lett, 2015 Jun 15. PMID 25916878
  3. The stum gene is essential for mechanical sensing in proprioceptive neurons. Desai BS, et al. Science, 2014 Mar 14. PMID 24626929
  4. Identification of a new allele of O-fucosyltransferase 1 involved in Drosophila intestinal stem cell regulation. Shi L, et al. Biol Open, 2021 Nov 15. PMID 34731235, Free PMC Article
  5. Spatial Comparisons of Mechanosensory Information Govern the Grooming Sequence in Drosophila. Zhang N, et al. Curr Biol, 2020 Mar 23. PMID 32142695, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in proprioception IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proprioception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of mechanical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in taxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in taxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sensory dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sensory dendrite IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
stumble
Names
CG30263-PB
CG30263-PD
CG30263-PE
stum-PB
stum-PD
stum-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21674901..21685000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137759.5 → NP_611603.3  stumble, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611603.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU83, Q9W2E1
    UniProtKB/TrEMBL
    A0A0B4KGB1
    Conserved Domains (1) summary
    pfam15795
    Location:1745 → 1833
    Spec3; Ectodermal ciliogenesis protein

  2. NM_001274196.2 → NP_001261125.2  stumble, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU83, Q9W2E1
    UniProtKB/TrEMBL
    A0A0B4KGB1
    Conserved Domains (1) summary
    pfam15795
    Location:1745 → 1833
    Spec3; Ectodermal ciliogenesis protein

  3. NM_001316430.1 → NP_001303359.1  stumble, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUQ1
    Conserved Domains (1) summary
    pfam15795
    Location:299 → 387
    Spec3; Ectodermal ciliogenesis protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGB1 A0A0B4KGB1
A0A126GUQ1 A0A126GUQ1
Q9W2E1.3 Q9W2E1

Gene LinkOut

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