Fmr1 - Fragile X messenger ribonucleoprotein 1

Enables several functions, including DEAD/H-box RNA helicase binding activity; N6-methyladenosine-containing RNA reader activity; and nucleic acid binding activity. Involved in several processes, including germ cell development; learning or memory; and regulation of nervous system development. Located in Golgi membrane; cytoplasmic ribonucleoprotein granule; and neuronal cell body. Part of RISC complex. Is expressed in several structures, including brain; germline cell; gonad; muscle cell; and somatic precursor cell. Used to study autism spectrum disorder; fragile X syndrome; and malignant pleural mesothelioma. Human ortholog(s) of this gene implicated in congenital myopathy 9A; congenital myopathy 9B; fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and primary ovarian insufficiency 1. Orthologous to several human genes including FXR1 (FMR1 autosomal homolog 1) and FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Nov 2024]

NCBI Orthologs

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