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MED16 Mediator complex subunit 16 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37535, updated on 9-Dec-2024

Summary

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Official Symbol
MED16provided by FlyBase
Official Full Name
Mediator complex subunit 16provided by FlyBase
Primary source
FLYBASE:FBgn0034707
Locus tag
Dmel_CG5465
See related
AllianceGenome:FB:FBgn0034707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5465; Dmel\CG5465; dTRAP95; med16; Med16; Sin4/TRAP95; Trap95
Summary
Enables transcription coregulator activity. Involved in regulation of transcription by RNA polymerase II; response to heat; and response to lipopolysaccharide. Part of mediator complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human MED16 (mediator complex subunit 16). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MED16 in Genome Data Viewer
Location:
58C5-58C7; 2-98 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22183138..22185892)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18070643..18073397)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 35 Neighboring gene Secreted Wg-interacting molecule Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Boube M, et al. Cell, 2002 Jul 26. PMID 12150923
  2. Natural Genetic Variation Screen in Drosophila Identifies Wnt Signaling, Mitochondrial Metabolism, and Redox Homeostasis Genes as Modifiers of Apoptosis. Palu RAS, et al. G3 (Bethesda), 2019 Dec 3. PMID 31570502, Free PMC Article
  3. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube M, et al. Genes Dev, 2000 Nov 15. PMID 11090137, Free PMC Article
  4. Differential Requirements for Mediator Complex Subunits in Drosophila melanogaster Host Defense Against Fungal and Bacterial Pathogens. Huang C, et al. Front Immunol, 2020. PMID 33746938, Free PMC Article
  5. Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. Terriente-Félix A, et al. Genetics, 2010 Jun. PMID 20233856, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription initiation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
part_of mediator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
mediator complex subunit 16
Names
CG5465-PA
MED16-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22183138..22185892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137806.4 → NP_611650.2  mediator complex subunit 16 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611650.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MT57, Q9GYW8, Q9W278
    Related
    FBpp0071684
    Conserved Domains (2) summary
    pfam11635
    Location:128 → 816
    Med16; Mediator complex subunit 16
    sd00039
    Location:91 → 131
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W278.2 Q9W278

Gene LinkOut

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