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PolE4 DNA polymerase epsilon subunit 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37560, updated on 9-Dec-2024

Summary

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Official Symbol
PolE4provided by FlyBase
Official Full Name
DNA polymerase epsilon subunit 4provided by FlyBase
Primary source
FLYBASE:FBgn0034726
Locus tag
Dmel_CG11301
See related
AllianceGenome:FB:FBgn0034726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
11301; BcDNA:GM21739; CG11301; Dmel\CG11301; Mes4; MES4; NF-Yc
Summary
Predicted to enable protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; endoderm anlage; ganglia; imaginal disc; and mesoderm. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See PolE4 in Genome Data Viewer
Location:
58D8-58D8; 2-99 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22411789..22412582)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18299294..18300087)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene quaking related 58E-3 Neighboring gene Ventrally-expressed protein D Neighboring gene quaking related 58E-1 Neighboring gene antisense RNA:CR45152 Neighboring gene quaking related 58E-2 Neighboring gene mitochondrial ribosomal protein S29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Genetic Basis of Natural Variation in Drosophila (Diptera: Drosophilidae) Virgin Egg Retention. Akhund-Zade J, et al. J Insect Sci, 2017 Jan. PMID 28042107, Free PMC Article
  2. Identification of the Drosophila Mes4 gene as a novel target of the transcription factor DREF. Suyari O, et al. Exp Cell Res, 2009 May 1. PMID 19150446
  3. Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of Drosophila Models for Studies. Yamaguchi M, et al. Int J Mol Sci, 2023 Apr 29. PMID 37175782, Free PMC Article
  4. NF-Y in invertebrates. Yamaguchi M, et al. Biochim Biophys Acta Gene Regul Mech, 2017 May. PMID 27793714
  5. Synchronous and stochastic patterns of gene activation in the Drosophila embryo. Boettiger AN, et al. Science, 2009 Jul 24. PMID 19628867, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of the Drosophila Mes4 gene as a novel target of the transcription factor DREF was confirmed.
    Title: Identification of the Drosophila Mes4 gene as a novel target of the transcription factor DREF.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of epsilon DNA polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of epsilon DNA polymerase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA polymerase epsilon subunit 4
Names
CG11301-PA
CG11301-PB
Mes4
Mesoderm-expressed 4
NF-YC-like
PolE4-PA
PolE4-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22411789..22412582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169782.2 → NP_001163253.1  DNA polymerase epsilon subunit 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163253.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSF2, Q9W256
    Conserved Domains (1) summary
    pfam00808
    Location:78 → 140
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

  2. NM_137825.4 → NP_611669.1  DNA polymerase epsilon subunit 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSF2, Q9W256
    Related
    FBpp0071738
    Conserved Domains (1) summary
    pfam00808
    Location:78 → 140
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W256.1 Q9W256

Gene LinkOut

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