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nsr novel spermatogenesis regulator [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37577, updated on 4-Jan-2025

Summary

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Official Symbol
nsrprovided by FlyBase
Official Full Name
novel spermatogenesis regulatorprovided by FlyBase
Primary source
FLYBASE:FBgn0034740
Locus tag
Dmel_CG3875
See related
AllianceGenome:FB:FBgn0034740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg3875; CG3875; Dmel\CG3875
Summary
Predicted to enable mRNA binding activity. Involved in post-transcriptional regulation of gene expression; sperm axoneme assembly; and sperm individualization. Located in nuclear speck. Orthologous to human KHDRBS2 (KH RNA binding domain containing, signal transduction associated 2) and KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See nsr in Genome Data Viewer
Location:
58F4-58F4; 2-100 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22650556..22653595)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18538061..18541100)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 6d2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45268 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes. Ding Y, et al. PLoS Genet, 2010 Dec 23. PMID 21203494, Free PMC Article
  2. Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila. Yang S, et al. PLoS Genet, 2008 Jan. PMID 18208328, Free PMC Article
  3. Asymmetric sequence divergence of duplicate genes. Conant GC, et al. Genome Res, 2003 Sep. PMID 12952876, Free PMC Article
  4. Quantitative evolutionary genomics: differential gene expression and male reproductive success in Drosophila melanogaster. Drnevich JM, et al. Proc Biol Sci, 2004 Nov 7. PMID 15539352, Free PMC Article
  5. Identification of atlastin genetic modifiers in a model of hereditary spastic paraplegia in Drosophila. Candia N, et al. Hum Genet, 2023 Aug. PMID 37368047

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative spermatogenesis regulator
Names
CG3875-PA
CG3875-PB
nsr-PA
nsr-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22650556..22653595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299807.1 → NP_001286736.1  putative spermatogenesis regulator, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286736.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E737, Q9W224
    Conserved Domains (1) summary
    cd02395
    Location:87 → 206
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

  2. NM_137838.3 → NP_611682.1  putative spermatogenesis regulator, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611682.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E737, Q9W224
    Related
    FBpp0071772
    Conserved Domains (1) summary
    cd02395
    Location:87 → 206
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W224 Q9W224

Gene LinkOut

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