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CG17807 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37585, updated on 4-Jan-2025

Summary

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Official Symbol
CG17807provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034748
Locus tag
Dmel_CG17807
See related
AllianceGenome:FB:FBgn0034748
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG17807
Summary
Predicted to enable tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity and tRNA binding activity. Involved in tRNA wobble uridine modification. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 71. Orthologous to human ALKBH8 (alkB homolog 8, tRNA methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG17807 in Genome Data Viewer
Location:
58F2-58F2; 2-100 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22634019..22635942, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18521524..18523447, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein S16 Neighboring gene Vacuolar protein sorting 20 Neighboring gene testes of unusual size Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase 9 Neighboring gene bonsai Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ALKBH8 as a potential N(6) -methyladenosine (m(6) A) eraser in insects. Dai Z, et al. Insect Mol Biol, 2023 Oct. PMID 37119026
  2. Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function. Hogan CA, et al. EMBO Rep, 2023 Oct 9. PMID 37642556, Free PMC Article
  3. tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory. Madhwani KR, et al. Proc Natl Acad Sci U S A, 2024 Nov 12. PMID 39495910, Free PMC Article
  4. Bonsaï, a ribosomal protein S15 homolog, involved in gut mitochondrial activity and systemic growth. Galloni M. Dev Biol, 2003 Dec 15. PMID 14651932
  5. Alkaline Ceramidase Mediates the Oxidative Stress Response in Drosophila melanogaster Through Sphingosine. Zhang CH, et al. J Insect Sci, 2019 May 1. PMID 31115476, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (uridine) methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17807-PA
NP_611690.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22634019..22635942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137846.3 → NP_611690.2  uncharacterized protein Dmel_CG17807 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611690.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9A3, Q9W232
    Related
    FBpp0071849
    Conserved Domains (3) summary
    cd12431
    Location:40 → 119
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    pfam08241
    Location:400 → 490
    Methyltransf_11; Methyltransferase domain
    cl21496
    Location:136 → 322
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T9A3 Q8T9A3
Q9W232 Q9W232

Gene LinkOut

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