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Cyp6d2 Cytochrome P450 6d2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37594, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp6d2provided by FlyBase
Official Full Name
Cytochrome P450 6d2provided by FlyBase
Primary source
FLYBASE:FBgn0034756
Locus tag
Dmel_CG4373
See related
AllianceGenome:FB:FBgn0034756
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6d2; CG4373; Dmel\CG4373
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in response to camptothecin. Is expressed in adult head; embryonic/larval tracheal section; and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cyp6d2 in Genome Data Viewer
Location:
58F4-58F4; 2-100 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22652573..22654530, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18540078..18542035, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene novel spermatogenesis regulator Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45268 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2. Thomas AM, et al. G3 (Bethesda), 2013 Jan. PMID 23316441, Free PMC Article
  2. Genome-wide expression analysis identifies a modulator of ionizing radiation-induced p53-independent apoptosis in Drosophila melanogaster. van Bergeijk P, et al. PLoS One, 2012. PMID 22666323, Free PMC Article
  3. Dietary Curcumin Intake and Its Effects on the Transcriptome and Metabolome of Drosophila melanogaster. Belcher S, et al. Int J Mol Sci, 2024 Jun 14. PMID 38928266, Free PMC Article
  4. Feminization of pheromone-sensing neurons affects mating decisions in Drosophila males. Lu B, et al. Biol Open, 2014 Feb 15. PMID 24463366, Free PMC Article
  5. DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid. Daborn P, et al. Mol Genet Genomics, 2001 Dec. PMID 11810226

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2.
    Title: Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to camptothecin IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 6d2
Names
CG4373-PA
Cyp6d2-PA
cytochrome P450
NP_611698.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22652573..22654530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137854.3 → NP_611698.1  cytochrome P450 6d2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611698.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W223
    Related
    FBpp0071839
    Conserved Domains (1) summary
    pfam00067
    Location:65 → 506
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W223.1 Q9W223

Gene LinkOut

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