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YME1L YME1 like ATPase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37636, updated on 4-Jan-2025

Summary

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Official Symbol
YME1Lprovided by FlyBase
Official Full Name
YME1 like ATPaseprovided by FlyBase
Primary source
FLYBASE:FBgn0034792
Locus tag
Dmel_CG3499
See related
AllianceGenome:FB:FBgn0034792
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3499; DmCG3499; Dmel\CG3499; dYME1L; dYME1L1
Summary
Predicted to enable ATP-dependent peptidase activity and metalloendopeptidase activity. Predicted to be involved in mitochondrial protein catabolic process and mitochondrial protein processing. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See YME1L in Genome Data Viewer
Location:
59B4-59B4; 2-101 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22882747..22886247, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18770270..18773770, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45469 Neighboring gene Phosphatidylinositol 4-phosphate 5-kinase 59B Neighboring gene ER membrane protein complex subunit 8/9 Neighboring gene asrij Neighboring gene GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase Neighboring gene Mediator complex subunit 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mitochondrial inner membrane AAA metalloprotease family in metazoans. Juhola MK, et al. FEBS Lett, 2000 Sep 15. PMID 10996302
  2. Autophagy accounts for approximately one-third of mitochondrial protein turnover and is protein selective. Vincow ES, et al. Autophagy, 2019 Sep. PMID 30865561, Free PMC Article
  3. Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration. Qi Y, et al. Cell Death Differ, 2016 Feb. PMID 26160069, Free PMC Article
  4. Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. Yoon W, et al. PLoS Genet, 2019 May. PMID 31125351, Free PMC Article
  5. Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1. Liu W, et al. Cell Death Differ, 2020 Jun. PMID 31907391, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD.
    Title: Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD.
  2. CG3499 encodes the Drosophila homolog of the human i-AAA protease YME1L.
    Title: Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of m-AAA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
YME1 like ATPase
Names
CG3499-PB
CG3499-PC
CG3499-PD
YME1L-PB
YME1L-PC
YME1L-PD
NP_001246473.1
NP_001261142.1
NP_726263.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22882747..22886247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274213.2 → NP_001261142.1  YME1 like ATPase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261142.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFY4
    Conserved Domains (4) summary
    TIGR01241
    Location:254 → 735
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:339 → 469
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:549 → 733
    Peptidase_M41; Peptidase family M41
    cl21455
    Location:302 → 358
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_166568.3 → NP_726263.1  YME1 like ATPase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726263.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1Y0
    Related
    FBpp0071817
    Conserved Domains (4) summary
    TIGR01241
    Location:261 → 732
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam00004
    Location:336 → 466
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam01434
    Location:546 → 730
    Peptidase_M41; Peptidase family M41
    cl21455
    Location:299 → 355
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001259544.2 → NP_001246473.1  YME1 like ATPase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246473.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F3YDF1, Q8MMD4, Q9W1Y0
    Conserved Domains (1) summary
    TIGR01241
    Location:254 → 736
    FtsH_fam; ATP-dependent metalloprotease FtsH
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFY4 A0A0B4KFY4
F3YDF1.1 F3YDF1

Gene LinkOut

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