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Gmer GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37638, updated on 4-Jan-2025

Summary

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Official Symbol
Gmerprovided by FlyBase
Official Full Name
GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductaseprovided by FlyBase
Primary source
FLYBASE:FBgn0267823
Locus tag
Dmel_CG3495
See related
AllianceGenome:FB:FBgn0267823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3495; Dmel\CG3495; DmGMER; GER; gmer; l(2)SH1931
Summary
Enables GDP-L-fucose synthase activity. Involved in 'de novo' GDP-L-fucose biosynthetic process. Predicted to be located in cytosol. Is expressed in organism. Orthologous to human GFUS (GDP-L-fucose synthase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Gmer in Genome Data Viewer
Location:
59B4-59B4; 2-101 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22887574..22888857, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18775097..18776380, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 4-phosphate 5-kinase 59B Neighboring gene ER membrane protein complex subunit 8/9 Neighboring gene YME1 like ATPase Neighboring gene asrij Neighboring gene Mediator complex subunit 23 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster. Rhomberg S, et al. FEBS J, 2006 May. PMID 16650000
  2. O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. Ishio A, et al. J Biol Chem, 2015 Jan 2. PMID 25378397, Free PMC Article
  3. Comparison of inter- and intraspecies variation in humans and fruit flies. Shih J, et al. Genom Data, 2015 Mar. PMID 26484147, Free PMC Article
  4. Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila. Ayukawa T, et al. Proc Natl Acad Sci U S A, 2012 Sep 18. PMID 22949680, Free PMC Article
  5. Helena and BS: Two Travellers between the Genera Drosophila and Zaprionus. Simão MC, et al. Genome Biol Evol, 2018 Oct 1. PMID 30165545, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cloning, purification and charactrization of Gmer
    Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GDP-L-fucose synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-L-fucose synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose 3,5-epimerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-sugar biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase
Names
CG3495-PA
GDP-keto-6-deoxymannose 3,5-epimerase/4-reductase
Gmer-PA
lethal (2) SH1931
NP_611734.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    22887574..22888857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137890.3 → NP_611734.1  GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611734.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1H8X1, Q8MS16, Q9W1X8
    UniProtKB/TrEMBL
    B6IDX2
    Related
    FBpp0071816
    Conserved Domains (2) summary
    cd05239
    Location:3 → 313
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
    pfam01370
    Location:4 → 234
    Epimerase; NAD dependent epimerase/dehydratase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1X8.1 Q9W1X8

Gene LinkOut

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