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Mthfs Methenyltetrahydrofolate synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37699, updated on 4-Jan-2025

Summary

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Official Symbol
Mthfsprovided by FlyBase
Official Full Name
Methenyltetrahydrofolate synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0085453
Locus tag
Dmel_CG34424
See related
AllianceGenome:FB:FBgn0085453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.139; CG11079; CG34424; Dmel\CG34424; MTHF
Summary
Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Mthfs in Genome Data Viewer
Location:
59D8-59D8; 2-102 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23359215..23360266)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19246738..19247789)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene virilizer Neighboring gene Interacts with the C terminus of ELL 1 Neighboring gene Golgin-245 Neighboring gene uncharacterized protein Neighboring gene yellow-d

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DASH-type cryptochromes - solved and open questions. Kiontke S, et al. Biol Chem, 2020 Nov 26. PMID 32663167
  2. RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance. Pawar V, et al. J Biomol Screen, 2011 Apr. PMID 21364088, Free PMC Article
  3. Differential gene expression related to Nora virus infection of Drosophila melanogaster. Cordes EJ, et al. Virus Res, 2013 Aug. PMID 23603562, Free PMC Article
  4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
  5. Drosophila anti-nematode and antibacterial immune regulators revealed by RNA-Seq. Castillo JC, et al. BMC Genomics, 2015 Jul 11. PMID 26162375, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-formyltetrahydrofolate cyclo-ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in folic acid-containing compound biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in folic acid-containing compound biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methenyltetrahydrofolate synthetase
Names
CG34424-PA
CG34424-PB
Mthfs-PA
Mthfs-PB
NP_001097432.1
NP_001286765.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23359215..23360266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103962.4 → NP_001097432.1  methenyltetrahydrofolate synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9XQB1, Q8MLS1
    Conserved Domains (1) summary
    cl00360
    Location:10 → 201
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

  2. NM_001299836.1 → NP_001286765.1  methenyltetrahydrofolate synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286765.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9XQB1, Q8MLS1
    Conserved Domains (1) summary
    cl00360
    Location:10 → 201
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MLS1 Q8MLS1

Gene LinkOut

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