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Ice1 Interacts with the C terminus of ELL 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37701, updated on 9-Dec-2024

Summary

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Official Symbol
Ice1provided by FlyBase
Official Full Name
Interacts with the C terminus of ELL 1provided by FlyBase
Primary source
FLYBASE:FBgn0034853
Locus tag
Dmel_CG13550
See related
AllianceGenome:FB:FBgn0034853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13550; dICE1; Dmel\CG13550; ICE1
Summary
Enables chromatin binding activity. Involved in snRNA transcription by RNA polymerase II. Located in euchromatin. Part of super elongation complex. Is expressed in larval muscle system; organism; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ice1 in Genome Data Viewer
Location:
59D9-59D9; 2-102 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23366866..23371459)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19254389..19258982)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene Methenyltetrahydrofolate synthetase Neighboring gene virilizer Neighboring gene Golgin-245 Neighboring gene uncharacterized protein Neighboring gene yellow-d Neighboring gene yellow-d2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Chung CY, et al. Nat Commun, 2018 Oct 23. PMID 30353006, Free PMC Article
  2. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Hu D, et al. Mol Cell, 2013 Aug 22. PMID 23932780, Free PMC Article
  3. Epigenetic Regulation of ALS and CMT: A Lesson from Drosophila Models. Yamaguchi M, et al. Int J Mol Sci, 2021 Jan 6. PMID 33419039, Free PMC Article
  4. Combinatorial modeling of chromatin features quantitatively predicts DNA replication timing in Drosophila. Comoglio F, et al. PLoS Comput Biol, 2014 Jan. PMID 24465194, Free PMC Article
  5. The little elongation complex regulates small nuclear RNA transcription. Smith ER, et al. Mol Cell, 2011 Dec 23. PMID 22195968, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in snRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in euchromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of super elongation complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription elongation factor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
NP_611786.1
  • interacts with the C terminus of ELL 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23366866..23371459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137942.2 → NP_611786.1  uncharacterized protein Dmel_CG13550 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611786.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MRC0, Q9W1R4
    Related
    FBpp0071919
    Conserved Domains (1) summary
    COG4372
    Location:25 → 129
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1R4.2 Q9W1R4

Gene LinkOut

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