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SkpF SKP1-related F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37713, updated on 4-Jan-2025

Summary

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Official Symbol
SkpFprovided by FlyBase
Official Full Name
SKP1-related Fprovided by FlyBase
Primary source
FLYBASE:FBgn0034863
Locus tag
Dmel_CG12227
See related
AllianceGenome:FB:FBgn0034863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12227; Dmel\CG12227; Skp; skpF
Summary
Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See SkpF in Genome Data Viewer
Location:
59E1-59E1; 2-103 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23458065..23458759, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19345588..19346282, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 59a Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 59b Neighboring gene Odorant receptor 59c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. Murphy TD. J Cell Sci, 2003 Jun 1. PMID 12730292
  2. Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. Roberts DM, et al. PLoS One, 2012. PMID 22359584, Free PMC Article
  3. The E3 ligase Poe promotes Pericentrin degradation. Galletta BJ, et al. Mol Biol Cell, 2023 Aug 1. PMID 37342879, Free PMC Article
  4. Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Ou CY, et al. Trends Genet, 2003 Jul. PMID 12850443
  5. Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity. Kumar T, et al. Elife, 2020 Sep 9. PMID 32901612, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SKP1-related F
Names
CG12227-PA
SkpF-PA
skpF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23458065..23458759 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137952.3 → NP_611796.1  SKP1-related F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611796.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W1Q0
    Related
    FBpp0071931
    Conserved Domains (3) summary
    smart00512
    Location:1 → 111
    Skp1; Found in Skp1 protein family
    COG5201
    Location:1 → 157
    SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
    pfam01466
    Location:87 → 157
    Skp1; Skp1 family, dimerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1Q0 Q9W1Q0

Gene LinkOut

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