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Argl Argininosuccinate lyase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3771738, updated on 4-Jan-2025

Summary

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Official Symbol
Arglprovided by FlyBase
Official Full Name
Argininosuccinate lyaseprovided by FlyBase
Primary source
FLYBASE:FBgn0032076
Locus tag
Dmel_CG9510
See related
AllianceGenome:FB:FBgn0032076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH06087; CG33085; CG9510; Dmel\CG9510; gh06087
Summary
Predicted to enable argininosuccinate lyase activity. Predicted to be involved in arginine biosynthetic process via ornithine. Predicted to be active in cytosol. Is expressed in anterior midgut primordium; embryonic proventriculus; embryonic proventriculus inner layer; embryonic/larval midgut; and posterior midgut primordium. Used to study argininosuccinic aciduria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Argl in Genome Data Viewer
Location:
29F5-29F5; 2-34 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8939725..8942105, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8939725..8942105, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46071 Neighboring gene Tetraspanin 29Fa Neighboring gene Tetraspanin 29Fb Neighboring gene uncharacterized protein Neighboring gene Core 1 Galactosyltransferase A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster. Chandrashekara KT, et al. Age (Dordr), 2014. PMID 25173182, Free PMC Article
  2. Gaining Insights into Diabetic Cardiomyopathy from Drosophila. Diop SB, et al. Trends Endocrinol Metab, 2015 Nov. PMID 26482877, Free PMC Article
  3. Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Heinrichsen ET, et al. Mol Metab, 2014 Feb. PMID 24567903, Free PMC Article
  4. Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics. Martelli F, et al. Cell Rep, 2024 Mar 26. PMID 38416643, Free PMC Article
  5. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables argininosuccinate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables argininosuccinate lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine biosynthetic process via ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine biosynthetic process via ornithine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
argininosuccinate lyase
Names
Argl-PB
Argl-PC
Argl-PD
CG9510-PB
CG9510-PC
CG9510-PD
NP_001027234.1
NP_001285768.1
NP_609257.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8939725..8942105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298839.1 → NP_001285768.1  argininosuccinate lyase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285768.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z741, Q86BM1, Q9VLG9
    Conserved Domains (2) summary
    cd01359
    Location:30 → 461
    Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    PRK00855
    Location:9 → 460
    PRK00855; argininosuccinate lyase; Provisional

  2. NM_135413.3 → NP_609257.3  argininosuccinate lyase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609257.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z741, Q86BM1, Q9VLG9
    Conserved Domains (2) summary
    cd01359
    Location:30 → 461
    Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    PRK00855
    Location:9 → 460
    PRK00855; argininosuccinate lyase; Provisional

  3. NM_001032063.2 → NP_001027234.1  argininosuccinate lyase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z741, Q86BM1, Q9VLG9
    Conserved Domains (2) summary
    cd01359
    Location:30 → 461
    Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    PRK00855
    Location:9 → 460
    PRK00855; argininosuccinate lyase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U189 Q5U189
Q8T444 Q8T444
Q960C6 Q960C6
Q9VLG9 Q9VLG9

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