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cana CENP-ana [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3771934, updated on 9-Dec-2024

Summary

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Official Symbol
canaprovided by FlyBase
Official Full Name
CENP-anaprovided by FlyBase
Primary source
FLYBASE:FBgn0040233
Locus tag
Dmel_CG33694
See related
AllianceGenome:FB:FBgn0040233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Cana; Cenp-E; CENP-E ana; CENPana; Cenp_E; CG32955; CG33694; CG4831; CP15516; DmCana; Dmel\CG33694; KIF 10; KIF10; l(2)k07716
Summary
Predicted to enable microtubule binding activity and plus-end-directed microtubule motor activity. Involved in metaphase/anaphase transition of mitotic cell cycle. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See cana in Genome Data Viewer
Location:
32E2-32E2; 2-44 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11269780..11277846)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11269780..11277846)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43859 Neighboring gene abrupt Neighboring gene CENP-meta Neighboring gene antisense RNA:CR44182 Neighboring gene uncharacterized protein Neighboring gene Palmitoyl-protein Thioesterase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Model of chromosome motility in Drosophila embryos: adaptation of a general mechanism for rapid mitosis. Civelekoglu-Scholey G, et al. Biophys J, 2006 Jun 1. PMID 16533843, Free PMC Article
  2. Chromosome motors on the move. From motion to spindle checkpoint activity. Brunet S, et al. EMBO Rep, 2001 Aug. PMID 11493594, Free PMC Article
  3. Senescence plays a role in myotonic dystrophy type 1. García-Puga M, et al. JCI Insight, 2022 Oct 10. PMID 36040809, Free PMC Article
  4. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. Yucel JK, et al. J Cell Biol, 2000 Jul 10. PMID 10893249, Free PMC Article
  5. Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes. Radford SJ, et al. PLoS Genet, 2015 Oct. PMID 26473960, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables plus-end-directed microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CENP-ana
Names
CG33694-PA
CG33694-PB
CG33694-PC
Kinesin7A
cana-PA
cana-PB
cana-PC
NP_001027247.1
NP_001285839.1
NP_001285840.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11269780..11277846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032076.2 → NP_001027247.1  CENP-ana, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027247.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NCF9, Q9VKH9
    Conserved Domains (6) summary
    smart00129
    Location:8 → 316
    KISc; Kinesin motor, catalytic domain. ATPase
    TIGR02168
    Location:471 → 1270
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR04523
    Location:924 → 1647
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    cl22853
    Location:8 → 310
    Motor_domain; Myosin and Kinesin motor domain
    pfam05837
    Location:1204 → 1266
    CENP-H; Centromere protein H (CENP-H)
    pfam07888
    Location:1489 → 1850
    CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like

  2. NM_001298911.1 → NP_001285840.1  CENP-ana, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J5P0
    Conserved Domains (2) summary
    COG1196
    Location:587 → 1344
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:100 → 763
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_001298910.1 → NP_001285839.1  CENP-ana, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285839.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J5P0
    Conserved Domains (2) summary
    COG1196
    Location:587 → 1344
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:100 → 763
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NCF9 Q9NCF9
Q9VKH9 Q9VKH9
X2J5P0 X2J5P0

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